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目的观察留兰香油中葛缕酮的气道扩张作用和对呼吸道介质的影响。方法用豚鼠药物引喘法、豚鼠离体气管片法、致敏豚鼠肺组织ＳＲＳＡ释放和拮抗ＳＲＳＡ、致敏豚鼠离体气管ＳｃｈｕｌｔｚＤａｌｅ反应法检测。结果葛缕酮对豚鼠药物性哮喘具有保护作用，灌胃给药延长５０％剂量为７６ｍｇ·ｋｇ－１，气雾给药为６３ｇ·Ｌ－１；对豚鼠离体气管有直接松弛作用，ｐＤ２值为４２７±００８，并有抗氨甲酰胆碱作用；能抑制致敏豚鼠肺组织ＳＲＳＡ的释放，ＩＣ５０为１８ｍｇ·Ｌ－１，拮抗ＳＲＳＡ收缩回肠的ＩＣ５０为２７ｍｇ·Ｌ－１，并能抑制致敏豚鼠离体气管的ＳｃｈｕｌｔｚＤａｌｅ反应。结论葛缕酮具有气道扩张作用和呼吸道抗过敏作用。
Objective To observe the airway dilatation and the effect on airway media in the setoperone in spearmint oil. Methods The guinea pig induced asthma method, the guinea pig isolated tracheal patch method, the sensitized guinea pig lung tissue SRS A release, and the antagonistic SRS A, sensitized guinea pig tracheal Schultz Dale reaction method. Results Gecosterone had protective effects on drug-induced asthma in guinea pigs. The 50% dose was prolonged by gavage at 7 6 mg·kg-1, and aerosol administration was 6 3 g·L-1. It had direct effects on isolated guinea pig trachea. Relaxation, pD2 value of 4 27 ± 0 08, and anti-carbachol effect; can inhibit the release of sensitized guinea pig lung tissue SRS A, IC50 of 18mg · L-1, antagonistic SRS A contraction The ileum has an IC50 of 27 mg·L-1 and can inhibit the Schultz-Dale response in isolated guinea pig trachea. Conclusion Gecuronone has airway dilatation and respiratory allergy.