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目的 探讨大肠癌病人nm23/NDPK和p53蛋白的表达与临床预后的关系及意义。方法 采用免疫组化SABC方法对126例大肠癌标本石蜡包埋组织进行了nm23/NDPK和p53蛋白的检测。结果 大肠癌组织中nm23和p53蛋白阳性率分别是91.3％和59.5％。两种蛋白产物的表达与癌组织学类型有关。结论 nm23和p53基因的丢失和突变可能导致了朋肠癌的发生,测定大肠癌组织中的nm23/NPK和p53蛋白的表达对判断病人的预后有积极的临床意义。
Objective To investigate the relationship between the expression of nm23/NDPK and p53 protein and clinical prognosis in patients with colorectal cancer. Methods Immunohistochemical SABC method was used to detect nm23/NDPK and p53 protein in 126 paraffin-embedded tissues of colorectal cancer. Results The positive rates of nm23 and p53 protein in colorectal cancer tissue were 91.3% and 59.5%, respectively. The expression of both protein products is related to the type of cancer histology. Conclusions The loss and mutation of nm23 and p53 genes may lead to the occurrence of colorectal cancer. The determination of nm23/NPK and p53 protein expression in colorectal cancer tissue has positive clinical significance in judging the prognosis of patients.