应用免疫组化法对３２例肝硬化活检或尸检肝组织中的增殖细胞核抗原（ＰＣＮＡ）进行了检测。２３例缺如（７１．９％），９例阳性（２８．１％），阳性细胞数少且与各例相差较大，多位于假小叶的边缘。相比之下，亚急性重型肝炎和重型慢性活动性肝炎肝组织中有较多的ＰＣＮＡ阳性细胞（Ｐ＜０．０５）。结果表明，肝硬化时肝细胞的增殖状态是相当低下的。 Immunohistochemistry was used to detect proliferating cell nuclear antigen (PCNA) in 32 liver biopsy or post-mortem liver tissues. 23 cases were absent (71.9%) and 9 cases were positive (28.1%). The number of positive cells was small and the difference with each case was large, mostly at the edge of pseudolobules. In contrast, there were more PCNA positive cells in the liver tissue of subacute severe hepatitis and severe chronic active hepatitis (P <0.05). The results show that liver cirrhosis proliferative state is quite low.