论文部分内容阅读
目的探讨PCT、CRP的联合检测在指导外科术后感染抗生素应用中的价值。方法选取2013年1月-2015年1月208例外科手术后感染患者,随机分为常规治疗组(对照组)、PCT指导治疗组(PCT组)、CRP指导治疗组(CRP组)和PCT联合CRP指导治疗组(PCT+CRP组),每组各52例。对照组根据患者症状、抗生素使用指南和医生经验常规使用抗生素;PCT组、CRP组及PCT+CRP组按照血清PCT、CRP水平决定是否使用或停用抗生素。分别统计分析4组的抗生素使用率、抗生素使用时间、平均住院时间、医疗费用及临床有效率。结果 PCT组、CRP组及PCT+CRP组抗生素使用率、使用时间、平均住院时间及医疗费用均低于对照组,差异有统计学意义(P<0.05),且联合组各项指标均低于其他3组,差异有统计学意义(P<0.05);4组患者治疗后的临床有效率、血清PCT水平、CRP水平及WBC水平比较,差异均无统计学意义(P>0.05)。结论联合检测血清PCT和CRP有助于指导外科术后感染患者抗生素使用,可有效减少抗生素的滥用及细菌耐药性的产生,提高临床疗效。
Objective To explore the value of combined detection of PCT and CRP in guiding the application of antibiotics after surgical infection. Methods A total of 208 patients with postoperative infection from January 2013 to January 2015 were randomly divided into routine treatment group (control group), PCT group (PCT group), CRP group (CRP group) and PCT group CRP guide treatment group (PCT + CRP group), each group of 52 cases. In the control group, antibiotics were routinely used according to the patient’s symptoms, guidelines for using antibiotics, and doctor’s experience. PCT, CRP and PCT + CRP groups decided whether to use or discontinue antibiotics according to serum PCT and CRP levels. The antibiotic use rate, antibiotic use time, average length of hospital stay, medical expenses and clinical efficiency of the four groups were statistically analyzed. Results The antibiotic use rate, duration of use, average length of hospital stay and medical expenses in PCT group, CRP group and PCT + CRP group were lower than those in control group (P <0.05), and the indexes in combination group were lower than The other three groups were significantly different (P <0.05). There was no significant difference in the clinical effective rate, serum PCT level, CRP level and WBC level between the four groups after treatment (P> 0.05). Conclusions Combined detection of serum PCT and CRP can help to guide the use of antibiotics in patients with postoperative surgical infection, which can effectively reduce the abuse of antibiotics and bacterial resistance, and improve the clinical efficacy.