出血是再生障碍性贫血三大主要症状之一,常常威胁患者生命,但对其发生机制的研究报告较少。过去一些学者多认为出血主要由于血小板减少和凝血因子的异常所致,但仅此点远不能解释临床上复杂的出血表现。近来虽有些学者注意到毛细血管机能和形态的变化与本病出血的关系,但还缺乏足够的实验根据。为了进一步探讨本病的出血机制,尤其是血管因素和血清素在出血中的作用,我们对65例再生障碍性贫血患者进行了比较系统的观察。方法与结果 Bleeding is one of the three main symptoms of aplastic anemia, often threatening the life of patients, but there are few reports on its mechanism. In the past, some scholars believe that bleeding is mainly due to thrombocytopenia and clotting factor abnormalities, but this point can not explain the clinical complex bleeding performance. Although some scholars recently noticed the capillary function and morphological changes and bleeding of the disease, but also lack sufficient experimental basis. In order to further explore the bleeding mechanism of this disease, especially the role of vascular factors and serotonin in the bleeding, we conducted a systematic review of 65 patients with aplastic anemia. Methods and results