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目的探讨D-二聚体含量在膀胱肿瘤诊断中的应用及手术创伤对其含量的影响。方法通过定量酶联免疫吸附试验对43例膀胱移行细胞癌患者行D-二聚体测定。结果肿瘤患者血浆D-二聚体含量较非肿瘤患者及正常组明显增高(P<0.01),水后膀胱肿瘤患者及非肿瘤患者血浆D-二聚体含量较术前明显增高(P<0.01),肿瘤患者高于非肿瘤患者(P<0.01)。结论膀胱肿瘤患者体内处于继发性纤溶活性增高状态。手术创伤可增强肿瘤患者和非肿瘤患者血浆纤溶活性增高状态。
Objective To investigate the application of D-dimer in the diagnosis of bladder cancer and the effect of surgical trauma on its content. Methods D-dimer was determined in 43 cases of transitional cell carcinoma of the bladder by quantitative enzyme-linked immunosorbent assay. Results The plasma D-dimer level in tumor patients was significantly higher than that in non-tumor patients and normal controls (P <0.01). The plasma D-dimer levels in patients with bladder cancer and non-tumor patients were significantly higher than those before operation (P <0.01) ), Tumor patients than non-tumor patients (P <0.01). Conclusions The patients with bladder cancer are in a state of secondary fibrinolytic activity. Surgical trauma can increase the status of plasma fibrinolytic activity in cancer patients and non-tumor patients.