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目的观察冬病夏治穴位敷贴联合孟鲁司特片治疗小儿咳嗽变异性哮喘的疗效及对免疫功能的影响。方法将81例咳嗽变异性哮喘患儿随机分为2组,对照组40例采用孟鲁司特片治疗,治疗组41例在对照组治疗方法的基础上联合冬病夏治穴位敷贴治疗,2组均以1月为1个疗程,1个疗程后比较2组的症状积分,用力肺活量(FEV)、第1秒用力呼气容积(FEV1)等肺功能指标及CD4~+,CD3~+,CD4~+/CD8~+等免疫功能指标的改善情况,比较2组的临床疗效及复发情况。结果 2组患儿咳嗽、气喘等症状积分均降低,FEV,FEV1水平均升高,但治疗组改善更显著,2组比较差异有统计学意义(P<0.05),对照组未见明显变化(P>0.05);治疗组CD4~+,CD3~+,CD4~+/CD8~+改善明显(P<0.05);治疗组总有效率优于对照组,且随访6月内的复发率低,2组比较差异有统计学意义(P<0.05)。结论冬病夏治穴位敷贴联合孟鲁司特片治疗小儿咳嗽变异性哮喘效果显著,可更好地改善肺功能及免疫功能,有效预防复发,值得临床推广。
Objective To observe the curative effect of winter sickness summer acupoint application combined with montelukast on children with cough variant asthma and its effect on immune function. Methods Eighty-one children with cough variant asthma were randomly divided into two groups. Forty patients in the control group were treated with montelukast tablets. In the treatment group, 41 cases were treated with the treatment of winter disease and summer acupoints on the basis of the control group, The two groups were treated with 1 course of treatment for 1 month. After 1 course of treatment, the lung function indices such as symptom score, forced vital capacity (FEV), forced expiratory volume in one second (FEV1), CD4 +, CD3 + , CD4 ~ + / CD8 ~ + and other immune function indicators to improve the situation, the two groups of clinical efficacy and recurrence. Results The scores of cough, asthma and other symptoms in both groups were decreased, the FEV and FEV1 levels were elevated, but the improvement in the treatment group was more significant (P <0.05), but there was no significant change in the control group P <0.05). The total effective rate of CD4 ~ +, CD3 ~ + and CD4 ~ + / CD8 ~ + in the treatment group was significantly improved than that of the control group (P0.05) The difference between the two groups was statistically significant (P <0.05). Conclusion The treatment of winter cough summer acupoints combined with montelukast tablets in children with cough variant asthma significantly, can better improve lung function and immune function, effective prevention of recurrence, is worthy of clinical promotion.