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目的:探讨骨碱性磷酸酶 (BAL P)检测在婴幼儿佝偻病诊断中的价值。 方法 :选择临床资料、病史、症状、体征、X线及血生化 (钙、磷、碱性磷酸酶 )检查和小儿 BAL P测定结果完整者 4 6 0例 ,对综合资料进行分析。 结果 :和田地区婴幼儿 BAL P界值点以 >2 0 0 U/ L 为宜。佝偻病占 4 6 .3% (2 13/ 4 6 0 ) ,以活动期为主 ,佝偻病血BAL P的检出率为 87.8% ,单纯钙的检出率为 11.2 % ,磷检出率为 13.1% ,碱性磷酸酶检出率为 6 3.4 % ,与患儿临床症状、体征的符合率达 89%以上 ,与 X线检查结果的符合率达 78.9%。 结论 :BAL P测定操作简单 ,病人痛苦小 ,特异性强 ,灵敏度高 ,所用设备简单 ,能快速得出检验结果。 BAL P的高低与婴幼儿佝偻病的严重程度呈正相关 ,依靠单纯 BAL P检测结果便可诊断佝偻病 ,值得在临床上推广应用
Objective: To investigate the value of bone alkaline phosphatase (BALP) in the diagnosis of infant rickets. Methods: The clinical data, medical history, symptoms, signs, X-ray and blood biochemistry (calcium, phosphorus, alkaline phosphatase) and pediatric BALP determination results were selected to analyze the comprehensive data. Results: BALP cut-off points of infants and young children in Wada were more than 200 U / L. Rickets accounted for 46.3% (2/13/4 6 0), mainly active stage. The detection rate of BALP in rickets was 87.8%, the detection rate of pure calcium was 11.2% and the detection rate of phosphorus was 13.1 %. The detection rate of alkaline phosphatase was 6.34%. The coincidence rate with clinical symptoms and signs of children reached more than 89%, and the coincidence rate with X-ray examination was 78.9%. Conclusion: BALP is simple and easy to operate, with little pain, strong specificity, high sensitivity, simple equipment and fast test results. The level of BAL P is positively correlated with the severity of infant rickets. The diagnosis of rickets can be diagnosed by BAL alone, which is worthy of clinical application