目的　了解系统性红斑狼疮 (SLE)患者的抑郁状况。方法　选择门诊和住院的 5 6例SLE患者 ,用抑郁自评量表 (SDS)进行问卷调查。结果　 4 1%SLE患者具有抑郁临床表现 ,其中易倦、兴趣丧失、性兴趣减退、绝望、易激惹、忧郁、思考困难、睡眠障碍、不安、生活空虚感等抑郁症状常见。抑郁临床表现患者中 ,以受教育程度低、从事体力劳动者为主 (P <0 0 5 ) ,抑郁表现与病程及婚姻相关 (P <0 0 5 ) ,与病情活动无关 (P >0 0 5 )。结论　在SLE患者中存在一定程度的抑郁症状 ,诊治过程中要关注患者的心理和情绪 Objective To understand the status of depression in patients with systemic lupus erythematosus (SLE). Methods Fifty-six outpatients and hospitalized patients with SLE were selected and the depression self-rating scale (SDS) was used for questionnaire survey. Results 4 1% of SLE patients had clinical manifestations of depression, of which depressive symptoms such as fatigue, loss of interest, decreased sexual interest, despair, irritability, depression, thinking difficulties, sleep disorders, anxiety and life emptiness were common. Among the patients with clinical manifestations of depression, those with low level of education and mainly manual workers (P <0.05), depression with duration of illness and marriage (P <0.05), had no correlation with illness activities (P> 0 0) 5). Conclusion There is a certain degree of depressive symptoms in SLE patients, the patient’s psychological and emotional