本文用发色底物法测定了30例急性脑血管意外患者急性期的血浆组织型纤溶酶原激活物及其抑制物的活性。发现脑血栓形成患者的 t—PA 活性高于正常,并与预后有关;脑出血患者 t—PA 活性明显低于正常,PAI 的活性在两组病例中无明显差别。急性期 t—PA 活性测出的结果在脑血栓形成和脑出血两组的不同,可能有鉴别诊断的意义。 In this paper, the chromogenic substrate method was used to determine the plasma levels of tissue-type plasminogen activator and its inhibitor in 30 patients with acute cerebrovascular accident. It was found that the activity of t-PA in patients with cerebral thrombosis was higher than normal and related to the prognosis. The activity of t-PA in patients with cerebral hemorrhage was significantly lower than that in normal patients. There was no significant difference in PAI activity between the two groups. Acute phase t-PA activity measured results in cerebral thrombosis and cerebral hemorrhage in two different groups may have the significance of differential diagnosis.