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目的 探讨北京地区汉族人群亚甲基四氢叶酸还原酶 (methylenetetrahydrofolatereduc tase ,MTHFR)基因C6 77T多态性与脑出血的相关性。方法 采用病例 对照研究方法和PCR RFLP方法检测 1 5 6例脑出血及 2 39例非脑血管病患者的MTHFR基因C6 77T多态性 ,用多元Logistic回归模型分析与脑出血的相关性。结果 经性别、年龄、吸烟、饮酒、文化程度、高血压、糖尿病、冠心病及血清总胆固醇水平调整后 ,经年龄分层 ,在≤ 6 0岁组中MTHFR基因TT基因型致脑出血发病危险性显著增加(OR =3.5 3,95 %CI :1 .0 5～ 1 1 .88) ;MTHFR基因C6 77T多态性与高血压对脑出血的发生具有明显协同作用。结论 MTHFR基因可能是≤ 6 0岁的中国汉族人群脑出血的遗传易感基因
Objective To investigate the association of C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene with cerebral hemorrhage in Han nationality in Beijing. Methods The case-control study and PCR-RFLP were used to detect MTHFR gene C677T polymorphism in 156 cases of cerebral hemorrhage and 239 cases of non-cerebrovascular disease. Multivariate logistic regression analysis was used to analyze the association with cerebral hemorrhage. Results The incidence of cerebral hemorrhage due to TT genotype of MTHFR gene in the age group of ≤60 years after adjustment for age, smoking, alcohol consumption, education level, hypertension, diabetes mellitus, coronary heart disease and serum total cholesterol level by age stratification (OR = 3.53,95% CI: 1.05 ~ 1.188). The C677T polymorphism of MTHFR gene and hypertension had a significant synergistic effect on the occurrence of cerebral hemorrhage. Conclusion The MTHFR gene may be a genetic predisposition to cerebral hemorrhage in Chinese Han population ≤60 years old