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本文总结了COMP方案和COEP方案治疗NHL、Ⅲ、Ⅳ病人19例.介绍了COMP和COEP的用法、用量、毒副作用及注意事项.治疗结果:COMP组,有效率100%,CR6例(占77.8%),PR3例(占22.8%).COEP组,有效率100%,CR6例,占(60%)PR4例占(40%).两方案的毒副作用均不严重,骨髓抑制Ⅰ°～Ⅱ°消化道反应Ⅰ°.经用COMP和COEP方案化疗的有效期1～5年,中位生存2.5年.尽管治疗NHL的方案较多,从各方案的疗效、复发情况及费用情况看,COMP和COEP均较其它方案为优,而且COMP和COEP较适应我国国情.
This article summarizes COMP and COEP regimen in 19 cases of NHL, Ⅲ, Ⅳ patients.The usage, dosage, side effects and precautions of COMP and COEP were introduced.Results: In the COMP group, the effective rate was 100%, CR6 (77.8 %) And PR3 (22.8%). COEP group, the effective rate was 100%, CR6 cases, accounting for 60% PR4 cases accounted for 40% .There was no serious side effects of the two programs, bone marrow suppression Ⅰ ° ~ Ⅱ ° Gastrointestinal reactions Ⅰ °. The duration of chemotherapy with COMP and COEP regimens is 1 to 5 years and the median survival time is 2.5 years. Although there are many regimens for the treatment of NHL, according to the efficacy, recurrence and cost of each regimen, COMP and COEP are superior to other programs, and COMP and COEP more suited to China’s national conditions.