肝纤维化是指由各种致病因子所致肝内结缔组织异常增生,导致肝内弥漫性细胞外基质过度沉淀的病理过程。近年来,“肝纤四项”检查已被认为是理想的诊断慢性肝病患者病情发展状况和治疗效果,衡量炎症活动度、纤维化程度的重要依据。本文通过检测120例慢性乙型肝炎患者血清Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、层粘连蛋白 Liver fibrosis is caused by a variety of pathogenic factors caused by abnormal proliferation of intrahepatic connective tissue, leading to excessive intrahepatic extracellular matrix deposition of the pathological process. In recent years, “liver fiber four ” examination has been considered as an ideal diagnosis of chronic liver disease in patients with disease progression and treatment, an important basis for measuring the degree of inflammatory activity, fibrosis. In this paper, 120 cases of chronic hepatitis B patients with serum type Ⅲ procollagen (PC Ⅲ), type Ⅳ collagen (Ⅳ-C), laminin