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作者报告了1982年泰国一乡村医院对313例疑似接触狂犬病的患者,使用单一部位皮内注射狂犬病疫苗的预防效果。观察对象年龄范围从11月龄至80岁。313例中206例为疯动物(主要是狗)咬伤者(四肢184例、躯干12例、头颈10例);接触疯动物唾液的非咬伤性暴露者107例。作者用法国Mérieux研究所的人二倍体细胞狂犬病疫苗(HDCV),于0、3、7、14和28天皮内接种0.1mlL免疫效价2.5 Iu/ml),根据情况给与1～5针免疫,接种4针以上的219例中,214例(97.7%)完成初次免疫。
The authors report on the prophylactic efficacy of a single-site intradermal injection of rabies vaccine in 313 patients who were suspected of having rabies in 313 villages in Thailand in 1982. Subjects range in age from 11 months to 80 years. Among the 313 cases, 206 were bitten by mad animals (mainly dogs) (184 limbs, 12 trunk and 10 head and neck); 107 were non-biting exposures to the saliva of the mad animals. The authors used a human diploid cell rabies vaccine (HDCV) at the Mérieux Institute in France with an intradermal dose of 0.1 ml of 2.5 Iu / ml on days 0, 3, 7, 14 and 28.) Needle immunization, vaccination of more than 4 needles in 219 cases, 214 cases (97.7%) to complete the initial immunization.