药物的作用性质、强度及毒副反应,除与其理化性质、剂量、剂型、给药途径有很大关系外,与给药时间(包括什么时间给药及给药间隔)有很大关系。从我们对某医院住院病人用药时间进行的调查(见表Ⅰ)来看,医护同仁对此仍重视不够。今就调查情况讨论如下。一、服药时间大部分不符合对剂型的生物利用度规律。药剂的生物利用度是指制剂服用后,药剂中药物被机体吸收进入血循环的程度(数量)和速度。生物利用度对药物疗效和毒副 In addition to its physical and chemical properties, dosage, dosage form, route of administration has a great relationship, and the administration time (including when the administration and interval) has a great relationship. From our survey on the inpatient medication time in a hospital (see Table I), our medical colleagues still pay insufficient attention to this. Now on the investigation of the situation are discussed below. First, taking most of the time does not meet the bioavailability of dosage forms. The bioavailability of a pharmaceutical agent refers to the degree (quantity) and speed of the drug in the pharmaceutical agent absorbed into the blood circulation by the body after taking the pharmaceutical preparation. Bioavailability of drug efficacy and toxic side effects