目的 TRPM8(Transient receptor potential melastatin 8)又称冷及薄荷醇感受器,是瞬时受体电位通道蛋白TRP家族的一员,参与机体冷感觉、痛觉、炎症反应、血管收缩与扩张、细胞生长增殖等调控。近年来发现TRPM8与肿瘤有密切关联,为研究肿瘤的发生发展、抗肿瘤天然药物的筛选以及肿瘤的靶向给药提供了重要线索,笔者就有关TRPM8的病理生理及调控机制的新近研究进行综述。 Objective TRPM8, also known as cold and menthol receptors, is a member of the transient receptor potential channel protein TRP family and is involved in the regulation of cold sensation, pain, inflammation, vasoconstriction and expansion, cell growth and proliferation . In recent years, it has been found that TRPM8 is closely related to tumor, which provides important clues for studying the occurrence and development of tumor, selection of anti-tumor natural drugs and targeted drug delivery. The review of recent studies on the pathophysiology and regulation of TRPM8 .