临床上可见到有些人因用某些药物(如磺胺、痢特灵,解热镇痛剂和抗癌药等)或吃鲜蚕豆等食品而引起黄疸,酱油色尿……,出现溶血性贫血。其多见原因是先天性葡萄糖-6-磷酸脱氢酶(G6PD)缺陷。一、G6PD与红细胞糖代谢成熟红细胞已无线粒体,只能依靠葡萄糖的无氧酵解(90％±)和磷酸戊糖通路代谢(10％±)获取能量。在磷酸戊糖通路中、葡萄糖经中心酶—G6PD催化还产生具有重要作用的还原型辅酶Ⅱ(NADPH)。二、NADPH的作用红细胞的主要功能是运输氧气,故受氧化的危险性大,而且 Clinically, some people can be seen because of certain drugs (such as sulfa, furazolidone, antipyretic analgesics and anti-cancer drugs, etc.) or eat fresh broad beans and other foods caused jaundice, soy sauce color urine ... ..., there hemolytic anemia . The most common reason is the congenital glucose-6-phosphate dehydrogenase (G6PD) defect. First, G6PD and erythrocyte metabolism of mature red blood cells have no mitochondria, can only rely on glucose anaerobic glycolysis (90% ±) and pentose phosphate pathway metabolism (10% ±) to obtain energy. In the pentose phosphate pathway, glucose catalyzes the production of reduced coenzyme II (NADPH), an important enzyme, through the central enzyme-G6PD. Second, the role of NADPH The main function of red blood cells is the transport of oxygen, so the risk of oxidation, and