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将BoPhoz类膦-氨基膦配体应用在Rh-催化β-脱氢氨基酸酯的不对称氢化反应中,考察了配体结构及反应条件对反应结果的影响,并在优化的条件下研究了各种底物的适用范围,产物的对映选择性达81%ee.
The application of BoPhoz phosphine-amino phosphine ligands in Rh-catalyzed asymmetric hydrogenation of β-dehydroamino esters was investigated. The effects of ligand structure and reaction conditions on the reaction results were investigated. Under optimized conditions, The scope of application of the substrate, the product of enantioselectivity up to 81% ee.