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AIM:To determine the plasma carnitine ester profile inadult patients with ulcerative culitis (UC) and comparedwith healthy control subjects.METHOD:Using ESI triple quadrupole tandem massspectrometry,the carnitine ester profile was measuredin 44 patients with UC and 44 age-and sex-matchedhealthy controls.RESULTS:There was no significant difference in thefasting free carnitine level between the patients withUC and the healthy controls.The fasting propionyl-(0.331±0.019 vs0.392±0.017 μmol/L),butyryl-(0.219±0.014 vs 0.265±0.012),and isovalerylcarnitine(0.111±0.008 vs 0.134±0.008) levels weredecreased in the UC patients.By contrast,the levelof octanoyl-(0.147±0.009 vs 0.114±0.008),decanoyl.(0.180±0.012 vs 0.137±0.008),myristoyl-(0.048±0.003 vs 0.039±0.003),palmitoyl-(0.128±0.006vs 0.109±0.004),palmitoleyl-(0.042±0.003vs 0.031±0.002) and oleylcarnitine (0.183±0.007vs 0.163±0.007; P<0.05 in all comparisons) wereincreased in the patients with UC.
AIM: To determine the plasma carnitine ester profile in adult patients with ulcerative culitis (UC) and compared with healthy control subjects. METHOD: Using ESI triple quadrupole tandem mass spectrometry, the carnitine ester profile was measured in 44 patients with UC and 44 age-and sex-matched health controls .RESULTS: There was no significant difference in the fasting free carnitine level between the patients with UC and the healthy controls. The fasting propionyl- (0.331 ± 0.019 vs 0.39 ± 0.017 μmol / L), butyryl- (0.219 ± 0.014 vs 0.265 ± 0.012), and isovalerylcarnitine (0.111 ± 0.008 vs 0.134 ± 0.008) levels were found in the UC patients. By contrast, the level of octanoyl- (0.147 ± 0.009 vs 0.114 ± 0.008), decanoyl (0.180 ± 0.012 vs 0.137 ± 0.008), palmitoleyl- (0.128 ± 0.006 vs. 0.109 ± 0.004), palmitoleyl- (0.042 ± 0.003 vs. 0.031 ± 0.002) and oleylcarnitine (0.183 ± 0.007 vs. 0.163 ± 0.007; P <0.05 in all comparisons were werecreased in the patients with UC.