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目的:探讨谷胱甘肽S-转移酶(GST)T1空白基因型和吸烟与散发性大肠腺癌(SCRAC)遗传易感性关联. 方法:应用多重PCR技术,检测GSTT1基因多态性. 结果:GSTT1空白基因型在吸烟大于10支/d的对照组和SCRAC组中的频率差异有显著性(X2=5.35,P=0.021), 在重度吸烟的远端SCRAC(X2=6.48,P=0.011)、非老年人SCRAC(X2=4.53,P=0.033)及低分化肿瘤(X2=4.02, P=0.045)与重度吸烟的对照组之间的频率差异均有显著性,不同Dukes分期重度吸烟的SCRAC分别与重度吸烟的对照组比较,GSTT1空白基因型频率的差异无显著性. 结论:GSTT1空白基因型提高了重度吸烟的个体患SCRAC 的危险陛,GSTT1空白基因型与重度吸烟的远端SCRAC 的易感性之间存在关联,肿瘤多见于非老年患者,多呈低分化性腺癌.
Objective: To investigate the association of glutathione S-transferase (GST) T1 genotypes with genetic susceptibility to smoking and sporadic colorectal adenocarcinoma (SCRAC) .Methods: The polymorphism of GSTT1 gene was detected by multiplex PCR.Results: There was a significant difference in frequency of GSTT1 null genotypes between SCRAC and control groups (X2 = 5.35, P = 0.021). In severe smoked distal SCRAC (X2 = 6.48, P = 0.011) , And there was significant difference in the frequency of SCRAC (X2 = 4.53, P = 0.033) and poorly differentiated tumors (X2 = 4.02, P = 0.045) There was no significant difference in the frequency of GSTT1 genotypes between the control and smoking groups, respectively.Conclusion: GSTT1 null genotypes increased the risk of SCRAC in severely smokers, while genotypes of GSTT1 null genotypes were significantly different from those of remote smoking SCRACs There is a correlation between susceptibility, cancer more common in non-elderly patients, mostly poorly differentiated adenocarcinoma.