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吡拉西坦是一种神经保护剂,能增加中风病人的局部脑血流量,改善临床预后。作者进行了一个多中心随机双盲试验以检验在发病后12小时内给药是否有益。 对象为入院时诊断为急性缺血性幕上性中风的病人,年龄在40～85岁,随机分组治疗。这些病人的发病时间均在12小时内,神经功能由Orgogozo评分标准确定为<70和>5。发病24小时内行CT扫描以证实诊断,如有必要可在8日内重复CT扫描,CT影像将显示有临床症状的非腔隙性幕上性梗塞(>1cm~2)。早期CT扫描可排除脑出血和(?)中线偏移的占位效应(≥0.5cm),还可排除木僵、昏迷(格拉斯哥昏迷评分<5)以及有后遗症的陈旧性中风和神经系统及其他系统的疾病。
Piracetam is a neuroprotective agent that increases the local cerebral blood flow in stroke patients and improves the clinical outcome. The authors conducted a multicenter randomized double-blind trial to test whether administration was beneficial within 12 hours of onset. Subjects were admitted to hospital diagnosed with acute ischemic supratentorial stroke patients, aged 40 to 85 years, randomized to treatment. The onset time for these patients was within 12 hours and neurological function was determined as <70 and> 5 by the Orgogozo score. Within 24 hours of the onset of CT scan to confirm the diagnosis, if necessary, repeat the CT scan within 8 days, CT images will show clinical symptoms of non-lacunar supracondylar infarction (> 1cm ~ 2). Early CT scans exclude mass-effect (≥0.5 cm) of cerebral hemorrhage and (-) midline shift, as well as stupor, coma (Glasgow coma score <5), and older sequelae with neurological and other sequelae and others System of disease.