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目的 探讨血液系统肿瘤化疗后粒细胞缺乏合并中、重度感染患者的抗生素经验性治疗。方法 对粒细胞缺乏合并中、重度感染的 40例患者给予头孢他啶或亚胺培南联合万古霉素治疗 ,对照组 32例给予单一头孢他啶或亚胺培南治疗。结果 治疗组有效率为 97.5 % ,对照组有效率为 84% ,联合用药组疗效明显高于单一用药组(P<0 .0 1)。结论 对粒细胞缺乏合并中、重度感染的血液肿瘤患者 ,应早期经验性选择足够的广谱抗生素治疗
Objective To investigate the empirical treatment of antibiotics in patients with agranulocytosis and moderate or severe infection after chemotherapy of hematological malignancies. Methods Ceftazidime or imipenem combined with vancomycin was given to 40 patients with agranulocytosis and moderate or severe infection, and 32 patients in control group were given ceftazidime or imipenem. Results The effective rate was 97.5% in the treatment group and 84% in the control group, and the effect in the combined group was significantly higher than that in the single group (P <0.01). Conclusion For patients with agranulocytosis who are complicated by moderate or severe infection, we should choose enough broad-spectrum antibiotics early enough