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神经系统退行性疾病的患病率随着人类寿命的持续增长和全球老年人口比例增大而不断增长,其中,阿尔兹海默症（AD）作为人类第一大神经系......
阿尔茨海默病（Alzheimer’s disease,AD）是一种以认知功能障碍为核心症状的神经退行性疾病,β-淀粉样蛋白（Amyloid-β,Aβ）代谢障碍是A......
＜正＞海马神经元是中枢神经系统的重要细胞之一，与认知功能有密切的联系[1]。二型糖尿病（type 2 diabetes mellitus,T2DM）大鼠海马损伤与......
阿尔兹海默病（Alzheimer’s disease, AD）是临床常见中枢神经系统退行性病变，其病因不明、病机不清，并对患者家庭和社会造成了巨大负担......
＜正＞阿尔茨海默病（AD）是一种常见的进行性神经退行性疾病，是老年人最常见的痴呆形式，其特征是记忆和认知功能的进行性障碍[1]。全世界有......
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阿尔茨海默病（Alzheimer’s disease,AD）是一种不可逆的中枢神经系统退行性疾病,是痴呆症中最常见的类型。AD的主要病理特征包括:淀......
目的阿尔茨海默病（Alzheimer’s disease,AD）是中老年群体高发的神经退行性疾病。肌醇需求酶1α（inositol-requiring enzyme-1α,IRE1......
目的:以“蛋白级联学说”为理论基础,观察莱菔硫烷（SFN）对阿尔兹海默病（AD）大鼠脑内Aβ的影响作用;观察AD大鼠脑胆固醇水平,探讨SFN对A......
阿尔茨海默症（Alzheimer’s disease,AD）是一种常见的神经系统退行性疾病,可导致渐进性的认知功能下降,对认知功能造成不可逆的影响......
淀粉样蛋白（β-amyloid, Aβ）沉淀是阿尔茨海默症（Alzheimer disease,AD）的重要病理特征之一。Aβ是由淀粉样前体蛋白（amyloid precurso......
阿尔茨海默氏病（Alzheimer’s disease,AD）是一种以渐进性记忆力丧失和认知障碍为主要症状的神经退行性疾病,在患者脑部出现两个明显......
学位
目的 观察Ndfip1在APP/PS1转基因小鼠大脑皮质和海马的分布和表达变化,以及Ndfip1与Aβ老年斑的定位关系;检测Ndfip1过表达对APPsw......
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目的 观察补肾活血法对快速衰老SAMP8小鼠学习记忆能力以及脑内β淀粉样蛋白(Aβ)和淀粉样品体裂解酶(BACE1)的影响,探究补肾活血......
阿尔茨海默症（Alzheimer’s disease,AD）是一种常见的神经退行性疾病,其具体发病机理尚不清楚,主要致病假说是Aβ蛋白沉积假说和Tau......
目的:铁是机体必需的金属离子之一,参与体内多种生物代谢过程,发挥重要作用。脑铁属于非血红素铁,在脑内分布广泛,其稳态平衡受到......
阿尔茨海默病(AD)是一种常见且不可逆转的神经退行性脑疾病,是老年人痴呆最常见的病因,临床表现有潜在的记忆和认知障碍、精神症状......
中国已经进入不可逆转的“老龄社会”。老年性痴呆（Alzheimer’s disease,AD）是一种最常见、患病率最高,以认知障碍为核心的慢性、进......
阿尔兹海默症（Alzheimer’s disease,AD）是一种以认知功能障碍和记忆力丧失为主要临床特征的神经退行性疾病,会对脑细胞及中枢神经系......
背景:选择素P（Selectin P）是一种选择素家族蛋白,源于血小板或血管内皮细胞,可溶性形式存在于血浆中,当血小板或内皮细胞激活时,选择......
目的:阿尔茨海默病（Alzheimer’s disease,AD）是最常见的一种慢性进行性的中枢神经系统退行性疾病,以痴呆为主要特征,表现为记忆障碍......
1研究目的阿尔茨海默氏病（AD）是一种特定的神经变性疾病,是老年人最常见的痴呆类型之一。临床特点是记忆缺损,学习能力下降,语言功能......
目的 探究CysLT1 R对APP-HEK293细胞中Aβ生成的影响并探寻其可能的作用机制.方法 构建慢病毒载体LV-CysLT1 R-EGFP并转染APP-HEK2......
阿尔茨海默病(Alzheimer\'s disease,AD)是老年人中最常见的神经退行性疾病,临床表现为进行性的认知障碍、行为紊乱及人格改变.......
Accumulation and aggregation of β-amyloid (Aβ) peptides result in neuronal death,leading to cognitive dysfunction in A......
认知缺陷是抑郁症的核心症状之一,已成为抑郁症治疗面临的的一大挑战.花榈木为我国南方广泛分布的一种绿色乔木,具有抗抑郁作用.然......
Objective Alzheimers disease(AD)is the most common form of dementia in elderly people....
Aim: Icariin (ICA) is a major fraction of flavonoids derived from the Chinese medical herb Epimedium brevicornum Maxim.O......
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ productio
Accumulation of β-amyloid(Aβ)peptide is critical for the pathogenesis of Alzheimers disease....
Effects of memantine on amyloid oligomer-induced impairment of synapticplasticity in vitro and in vi
Soluble amyloid-β protein (Aβ) plays a central pathogenic role in Alzheimers disease (AD).Memantine, a low-affinity N-......
Objective Death receptor 6 (DR6) is a death domain-containing receptor of the TNFR superfamily with an apparent regulato......
目的：观察apelin-13 是否通过影响ABCA1 蛋白水平从而调节Aβ 代谢。方法：①Western blot 检测PC-12细胞血管紧张素受体AT1 相关的受......
Alzheimers disease(AD),the most common cause of dementia among neurodegenerative diseases in the elderly population,is c......
Melatonin prevents against the neurotoxicity of amyloid β protein in long-term potentation and neuro
Melatonin, an indole hormone secreted by the pineal gland, has been reported to have strong neuropeotective effects.Howe......
Triptolide improves learning and memory behavior of the 5XFAD transgenic mice accompanied by suppres
Triptolide (T10) is a major active component of the traditional Chinese medicine, Tripterygium wilfordii Hook F (TWHF), ......
Some new recognitions of pathologic feature of AD patients have provided new important clues about the mechanisms of neu......
阿尔茨海默病(Alzheimers disease,AD)是一种中枢神经退行性病变疾病,年龄是AD 发生的风险因素,65 岁以上老年痴呆的年平均发病率......
Downregulating IGF-1R alleviates β-amyloid deposition in cortex induced by chronic sleep restriction
Aim In chronic sleep restriction(CSR)mice model,we have showed the Aβ accumulation in frontal cortex in adult wildtype(......
Administration of COG1410 Reduces Aβ deposition and ameliorates cognitive deficits after traumatic b
Traumatic brain injuryas a cause of progressive neurodegenerative disorders and display Alzheimers disease(AD)-like cogn......
Rosiglitazone rescue amyloid oligomer-mediated synaptic plasticity and synaptic development impairme
Emerging evidence indicates that rosiglitazone, a potent agonist of peroxisome proliferator-activated receptor gamma (PP......
Rosiglitazone rescues soluble amyloid oligomer-induced impairment of synaptic development and plasti
Recent evidence indicates that rosiglitazone, a potent agonist of peroxisome proliferator-activated receptor gamma (PPAR......
O-GalNAc 糖基化是一种重要的蛋白质糖基化修饰形式,与蛋白的加工剪切等过程密切相关。多肽：N-乙酰氨基半乳糖转移酶(ppGalNAc-T)是......
The pathological α-synuclein transmission in brain of a transgenic mouse model of Alzheimer‘s diseas
Alzheimers disease(AD)and Parkinsons disease(PD)are common neurodegenerative diseases.There is comorbidity of AD and PD ......
目的：研究一种新型的PDE5抑制剂——优克那非改善APP/PS1双转基因小鼠认知功能的作用,并探讨其作用机制。方法：通过化学分析方法考察......
目的:探讨肉苁蓉皂苷对β淀粉样蛋白(Aβ25-35引起的人脑神经瘤母细胞SH-SY5Y细胞毒性的保护作用.方法:MTT法确定Aβ25-35诱导SH-S......
Cryptotanshinione inhibits β-amyloid aggregation and protects damage from β-amyloid in SH-SY5Y cells
The deposition of amyloid β-protein (Aβ) fibrils into plaques within the brain parenchyma and along cerebral blood ves......
