GENOMICS相关论文
The antifungal caspofungin is a semi-synthetic derivative of the lipohexapetide pneumocandin B_0 produced by the fungus ......
Integrative omics analysis identifies macrophage migration inhibitory factor signaling pathways unde
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目的分析神经危重症感染患者肺炎克雷伯病原菌（Klebsiella pneumoniae，KP）同源性与基因组学的关系。方法选取2015-2018年神经危重症感......
目的通过转录组和蛋白组数据关联分析，筛选低剂量电离辐射效应相关基因，为低剂量辐射效应的分子机制研究提供新思路。方法于2018年3......
随着技术的不断革新，基因组学及其他组学技术，如转录组学、蛋白质组学、代谢组学，日益成为精准医疗的重要基础。目前职业性噪声听力损......
出生缺陷与罕见病已成为重大公共卫生问题，早期防控和阻断是目前最有效的干预措施。近年来随着高通量测序等基因组检测技术的飞速发......
遗传因素是出生缺陷发生的主要原因。通过对基因组学领域的深入研究以及应用分子生物学技术，在健全的出生缺陷三级预防体系下，从孕前......
<正>中国药企可以利用并购、合作等非研发创新的路径来快速进入新市场,并建立起新的能力拓展产品组合。许多大型中国药企展示出跻......
抑郁症是一种常见的心理、精神障碍，本病具有反复发作，治疗难度大，疗效差等迫切的现实问题。其根源在于医学对本病认识有限及本病发生......
目的 筛选出创伤性脑损伤(TBI)大鼠海马的差异表达基因.方法 TBI组(3只)采用液压冲击装置,建立大鼠中度TBI模型.对照组(5只)除不予......
Molecular Biology based on the DNA Double-helix structure has made great progress in 20 century.After Human Genome Proje......
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Systems biology is an emerging science of the 21st century and its method and design of study resemble those of traditio......
近年来人类基因组的研究以及基因学(Genomics)研究的进展,已大大加快对疾病基因的了解,80年代科学家化了9年时间鉴别出囊性纤维化......
The Human Genome Project was launched at the end of the 1980s.Since then,the cloning and identification of functional ge......
药物作用机制的研究是药物研发的重要组成部分,具有重要意义。基因组学、转录组学、蛋白质组学和代谢组学等组学研究方法近年来已......
The development of replacement heifers is at the core of cow-calf beef production systems. In 2020, the USDA, National A......
Phylogeography of SARS-CoV-2 pandemic in Spain:a story of multiple introductions,micro-geographic st
Spain has been one of the main global pandemic epicenters for coronavirus disease 2019(COVID-19).Here,we analyzed ＞41 000......
媒介昆虫是一类通过吸血传播病原的节肢动物,主要包括蚊虫、猎蝽、蚤、蠓和白蛉等.媒介昆虫能够传播多种传染性致病因子,在人群中......
High-throughput sequencing is a revolutionary technological innovation in DNA sequencing.This technology has an ultra-lo......
Precision health refers to personalized healthcare based on a person’s unique genetic,genomic,or omic composition withi......
Germline genomes have a dominant-heritable contribution to cancer immune evasion and immunotherapy r
Background: Immune evasion is a fundamental hallmark for cancer.At the early stages of tumor development,immune evasion ......
The complex pattern of cancer evolution poses a huge challenge to precision oncology.Longitudinal sequencing of tumor sa......
,A Chromosome-Scale Genome Assembly of Paper Mulberry (Broussonetia papyrifera)Provides New Insights
Paper mulberry (Broussonetia papyrifera) is a well-known woody tree historically used for Cai Lun papermaking,one of the......
Neospora caninum (N.caninum),a cyst-forming protozoan parasite,is a major cause of bovine abortions and neonatal mortali......
近日,中国农业科学院烟草研究所烟草功能基因组创新团队有关细胞壁多糖代谢膨胀素基因研究取得新进展,相关结果分别发表于《植物细......
目前的研究公认精神分裂症的病因及病理机制极为复杂，临床表现异质性以及对治疗反应的异质性也极大。《世界精神病学杂志》曾专刊论......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
唾液作为一种辅助诊断性的体液，具有留取简便易行、非侵入性及安全的优点而备受研究者青睐。唾液的蛋白质组学、基因组学研究极大提......
目的探讨7型腺病毒肺炎患者的临床表现及7型腺病毒株（CHN/BeiJing/2018）的基因组学特征。方法收集2017年10月27日至2018年2月28日北......
肠道菌群寄居在人体胃肠道内各个部位,是一个种类繁多、动态变化的微生物群体.越来越多的研究表明,肝硬化、肝性脑病、非酒精性脂......
目的 探讨一株分离自关节假体周围感染（periprosthetic joint infections，PJI）患者假体的临床金黄色葡菌球菌是否适合作为PJI致病机制......
The last ten years have seen remarkable progress in cancer research.However,despite significant breakthroughs in the und......
肠道菌群是人体最大的微生物群体,参与机体多种生理过程,肠道菌群紊乱与人类多种疾病有关.由于肝脏和胃肠道之间相互作用、相互影......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Genomics in personalized cancer medicine and its impact on early drug development in China:report fr
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Posterior fossa ependymoma comprises two distinct molecular entities,ependymoma_posterior fossa A(EPN_PFA)and ependymoma......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
1 IntroductionrnSince human genome sequencing has been almost completed, human genome project will quickly move on to th......
[目的]探讨成人原发性腹股沟疝基因组学的相关变异.[方法]利用基因芯片技术对原发性腹股沟疝患者的腹横筋膜与正常腹横筋膜进行检......
新版对生物制品的质量要求更高,其中对生物制品宿主细胞蛋白(host cell protein,HCP)残留量的限制也更严格.新兴的系统生物学(包括......
近年来新型DNA测序平台454、Solexa、SOLiD、Polonator和HeliSeope等得到迅速推广,使测序成本下降了2-3个数量级.原先只能由大型测......
Publicly-accessible resources have promoted the advance of scientific discovery. The era of genomics and big data has br......
Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the sca......
近年来,纳米材料药物因其独特的生物学特性而被广泛应用于医疗领域,但其安全性问题已成为广大学者所关注的焦点。基因组学和蛋白组......
Genomics in personalized cancer medicine and its impact on early drug development in China:report fr
The 6th Annual Meeting of the United States Chinese Anti-Cancer Association (USCACA) was held in conjunction with the 50......
目的 通过基因芯片寻找大鼠激素性股骨头坏死组织中表达变化的基因,尝试探讨激素诱发股骨头坏死的始动因素和分子机制.方法 2007年......
Next-generation sequencing(NGS) technology, with its high-throughput capacity and low cost, has developed rapidly in rec......
Transcriptome and Proteome Expressions Involved in Insulin Resistance in Muscle and Activated T-Lymp
We analyzed the genes expressed (transcriptomes) and the proteins translated (pro- teomes) in muscle tissues and activat......
