PI3KAktpathway相关论文
Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lu
Long non-coding RNA (lncRNA) FOXD3-AS1 expression is upregulated in lung cancer;however,its effect and mechanism on 5-fl......
Progestin and adipoQ receptor 4 (PAQR4) is a novel tumorigenic factor that promotes cell prolif-eration and metastasis i......
The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymu......
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Luteinizing Hormone Induces Androgen Production in Goat Theca Cells via Activation of the PI3K/Akt P
Objectives: Theca cells play an important role in maintaining follicles development, particularly, in controlling ovaria......
Liensinine induces gallbladder cancer apoptosis and G2/M arrest by inhibiting ZFX-induced PI3K/AKT p
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目的 Hyperoxic acute lung injury(HALI)is a clinical syndrome as a result of prolonged supplement of high concentrations ......
Objective Breast cancer is one of the most common malignancies in women worldwide.In China,breast cancer alone accounted......
PI3K/AKT pathway interacts with hypoxia-inducible factor-1α(HIF-1α)to promote the development of bre
Objective Previous studies have shown that the overexpression and dysfunction of HIF-1α caused by genetic alternations ......
tripterygium glycoside up-regulat autophagy to protect the podocyte injury induced by puromycin amin
Background:Tripterygium glycoside(TG),one of the active ingredients of Tripterygium wilfordii Hook F(TwHF),a widely used......
Co-targeting of CK2α and YBX1 triggers additive anti-proliferation and anti-migration effects in can
The PI3K/AKT pathway plays important roles in the pathogenesis and progression of cancers.Protein kinase CK2 alpha(CK2α......
Stel B (Stellettin B) was isolated from marine sponge Jaspis stellifera.In vitro antitumor activities were investigated ......
tripterygium glycosideupregulateautophagy to protect the podocyte injuryinduced by puromycin aminonu
Background:Tripterygium glycoside(TG),one of the active ingredients of Tripterygium wilfordii Hook F(TwHF),a widely used......
Objective The etiology of in?ammatory myo?broblastic tumors (IMT) is controversial and the prognosis is unpredictable.Pr......
目的：探讨DEC1在多巴胺能神经元(SH-SY5Y)神经毒素(MPP+)诱导细胞凋亡中的作用.方法：SH-SY5Y细胞分别用生理盐水、不同浓度的MPP+处......
The basic helix-loop-helix (bHLH) transcription factor, DEC1, provides neuroprotection from apoptosi
OBJECTIVE To determine the role of the basic helix-loop-helix (bHLH) transcription factor, differentiated embryonic chon......
Inhibiting glucose transporter-1 and the PI3K/Akt pathway with apigenin, siRNA, LY294002 or wortmann
Background We first hypothesized that targeting glucose transporter-1 (GLUT-1) and the phosphatidylinositol 3-kinase/pro......
Feedback loops blockade potentiates antitumor activity of a novel AKT1 inhibitor DC120 in human live
The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic target.However,relief of fee......
Aims: To investigate the in vitro and in vivo anti-tumor effect of Pulsatilla saponins,the major components extracted fr......
Stel B (Stellettin B) was isolated from marine sponge Jaspis stellifera.In vitro antitumor activities were investigated ......
HL-60 cell line was originated from a female patient with acute promyelocytic leukemia(APL),whose features have made its......
Background: Increasing evidences demonstrate that miRNAs contribute to development and progression of hepatocellular car......
Cbl-b and PI3K/Akt pathway are differently involved in oxygen-glucose deprivation preconditioning in
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Prostate specific membrane antigen knockdown impairs the tumorigenicity of LNCaP prostate cancer cel
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NALP1 Inflammasome Inhibition Contributes to Aspirin-Triggered Lipoxin Rescued Morphine Anti-nocicep
Clinical usage of opioids in pain relieving was dampened by analgesic tolerance after chronic exposure.The contribution ......
目的了解银杏内酯B(GKB)对癫痫大鼠海马中低氧诱导因子-1α(HIF-1α)与磷脂酰肌醇-3激酶/丝氨酸-苏氨酸蛋白激酶(PI3K/Akt)的影响，......
Vascular endothelial growth factor：an attractive target in the treatment of hypoxic/ischemic brain i
Cerebral hypoxia or ischemia results in cell death and cerebral edema, as well as other cellular reactions such as angio......
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目的 观察运动训练对脑缺血大鼠磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)抗凋亡信号转导通路的影响,探讨运动训练促进脑缺血后神经功......
