acetylation相关论文
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mi
Parkin,an E3 ubiquitin ligase,plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondr......
LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppres
Large tumor suppressor 1 (LATS1) is the key kinase controlling activation of Hippo signalling pathway.Post-translational......
SL010110,a lead compound,inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and imp
Suppression of excessive hepatic gluconeogenesis is an effective strategy for controlling hyperglycemia in type 2 diabet......
Hypertrophic preconditioning attenuates myocardial ischemia/reperfusion injury through the deacetyla
To test the hypothesis that transient nonischemic stimulation of hypertrophy would render the heart resistant to subsequ......
Icariin Improves Cognitive Impairment after Traumatic Brain Injury by Enhancing Hippocampal Acetylat
Objective: To examine the effect of icariin (ICA) on the cognitive impairment induced by traumatic brain injury (TBI) in......
Mass spectrometry analysis of the variants of histone H3 and H4 of soybean and their post-translatio
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Thermo-Mechanical Properties of the Composite Made of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) a
The polar hydroxyl groups on the polysaccharide nanocrystals inhibit the positive function of the polysaccharide nanocry......
High Glucose-induced TRIB3 Promotes CRC Tumorigenesis and Progression via Upregulating Wnt/betacaten
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Insulin-Like Growth Factor 1 Induced Enolase 2 Deacetylation by Histone Deacetylase 3 Promotes Metas
Objective Background and Aims: Although the dysregulation of lysine acetylation(Kac)in the majority of intermediate meta......
Objective Non-histone protein acetylation in cancer cell regulates diverse biological functions that have been associate......
Genes that exhibit differential expression behaviors are called pattern genes (Pan et al.,2012).Four kinds of pattern ge......
Ribonucleotide reductase(RNR),composed of RRM1 and RRM2 subunits,catalyzes the rate-limiting step in the de novo synthes......
HBO1,a member of the MYST family histone acetyltransferases(HATs),is required for global acetylation of H3K14 and embryo......
The abundant expression of IFNγ in ThPOK-deficient CD4+ T cells requires the activation of Eomesodermin (Eomes);however......
Osterix (Osx) , a C2H2-type zinc-finger containing transcription factor, plays an essential role in controlling osteobla......
Acetylation of Bovine Foamy Virus Transactivator BTas by p300 Augments Promoter-binding Affinity and
Recent reports showed that several histone acetyltransferases (HATs) could acetylate transactivators of retrovirus and s......
Reducing the cytotoxicity while improving the anti-cancer drug loading capacity of polypropylenimine
Polypropylenimine (PPI) dendrimers have been widely used as effective deliveryvehicles for drugs and nucleic acids durin......
PhoP is an essential transcription factor for virulence in Salmonella.Our previous study showed that the acetylation of ......
As a genome guardian,p53 maintains genome stability by arresting cells for damage repair or inducing cell apoptosis to e......
Reducing the cytotoxicity while improving the anti-cancer drug loading capacity of polypropylenimine
Polypropylenimine (PPI) dendrimers have been widely used (i)s effective delivery vehicles for drugs and nucleic acids du......
Interferon regulatory factor-1 mediates the release of high mobility group box-1 in endotoxemia in m
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Ubiquitin-specific protease 31 (USP31) is a member of deubiquitinase family that is involved in nuclear factor-κB activ......
A domesticated Harbinger transposase forms a complex with HDA6 and promotes histone H3 deacetylation
In eukaryotes,histone acetylation is a major modification on histone N-terminal tails that is tightly connected to trans......
Barley NLR Receptor Triggers Immunity by Derepressing Defense Transcriptions through Acetylation and
Plant employs NLR receptors to recognize isolate-specific effectors and induce massive transcriptional reprogramming......
The tumor suppressor protein p53 is a well-known transcription factor that functions as a critical component of the geno......
A biomarker is a measurable indicator associated with changes in physiological state or disease.In contrast to the blood......
SYNTHESIS AND STRUCTURE OF α’-ACE-TYL-α-THIENYL PHENYLACETYLENEDI-COBALT HEXACARBONYL AND α’-ACE-TYL
Friedel-Crafts acylation of α-thienyl phenylacetylenedicobalt hexacarbonyl with acetyl chlo-ride has been investigated.......
目的探索高氟暴露是否会影响外周血组蛋白乙酰化水平，氟骨症患者的组蛋白乙酰化水平是否存在异常，尝试从转录修饰水平上研究氟骨症的......
目的 探讨低剂量无机砷对人正常肝细胞(L-02)中Sirt1及细胞周期相关基因表达的影响.方法 0.0(对照)、0.1、0.2、0.4 μmol/L三氧化......
Slug,a member of the Snail family of transcriptional repressors,plays a key role in cancer progression,cellular plastici......
目的探讨西罗莫司诱导K562细胞γ珠蛋白基因表达的作用机制。方法终浓度10 nmol·L-1西罗莫司处理K562细胞3 d,同时设立阳性药物(......
Tubulin posttranslational modifications (PTMs) add “tubulin code” to generate functional diversities of microtubules.S......
目的:构建大鼠p300基因短发夹状小干扰RNA(short hairpin RNA,shRNA)真核表达质粒,观察沉默p300基因对亚溶解型(sublytic)C5b-9诱......
目的:探讨组蛋白去乙酰化酶抑制剂(histone deacetylase inhibitor,HDACi)曲谷抑霉素A(trichostain A,TSA)对人干扰素调节因子3 (i......
目的:探讨KLF7b对斑马鱼胚胎发育的影响.方法:体外转录野生型KLF7b m RNA、KLF7b乙酰化位点突变体m RNA;设计合成特异性KLF7b反义......
目的:探讨p300/CBP是否参与介导了孕期酒精暴露所致的心脏核心转录因子GATA4和NKX2.5的过表达,为防治酒精所致的先天性心脏病提供......
Sirt1 inhibits renal tubular cell epithelial-mesenchymal transition through YY1 deacetylation in dia
Silent information regulator 1(Sirt1)is a deacetylase,which plays an important role in the occurrence and development of......
组蛋白去乙酰化酶抑制剂(histone deceatylase inhibitor,HDACi)是一类抑制组蛋白去乙酰化的有机化合物,通过改变组蛋白乙酰化程度......
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Lysine acetylation, first identified in histones, was initially thought to be a posttranslational modification occuring ......
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,FK228 induces mitotic catastrophe in A549 cells by mistargeting chromosomal passenger complex local
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The p53 tumor suppressor is a sequence-specific transcription factor that undergoes an abundance of post-translational m......
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,E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING fi
UHRF2 is a ubiquitin-protein ligase E3 that regulates cell cycle,genomic stability and epigenetics.We conducted a co-imm......
