A Novel ATRA derivative N-(3-trifluoromethyl-phenyl)-retinamide (ATPR) inhibits lung adenocarcinoma

来源 :2014年第十二届全国脂质与脂蛋白学术会议 | 被引量 : 0次 | 上传用户：shmilyuho

【摘要】

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Objective: To observe the effects of a novel ATRA derivative ATPR on lung adenocarcinoma A549 cells and to explore the probable mechanism of ATPR inhibiting A54

【作者】

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Tingting Fan Shuyu Gui Feihu Chen Qing Zhou Yuan Wang

【机构】

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LaboratoryofMolecularBiology,AnhuiMedicalUniversity

【出处】

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2014年第十二届全国脂质与脂蛋白学术会议

【发表日期】

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2014年10期

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Objective: To observe the effects of a novel ATRA derivative ATPR on lung adenocarcinoma A549 cells and to explore the probable mechanism of ATPR inhibiting A549 cells migration.Methods: The cytotoxicity of ATRA and ATPR on A549 cells was assessed using MTT assay.Wound healing assay was used to analyze the influence of ATRA, ATPR, ML-7 (a high selective inhibitor of MLCK), PMA (an activator of MAPKs) and PD98059 (a high selective inhibitor of ERK1/2) on the migration of A549 cells.And the expression of MLCK and phosphorylation of myosin light chain (MLC) was performed by western blot.

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A Novel ATRA derivative N-(3-trifluoromethyl-phenyl)-retinamide (ATPR) inhibits lung adenocarcinoma

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