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Mesoporous silica nanoparticles (MSN) have recently received considerable attention as carriers for the controlled drug release.Poly(N-vinyl caprolactam) (PVCL) is a representative thermosensitive polymer with excellent biocompatibility,which does not produce poisonous small amide compounds during its hydrolysis compared with the most extensively studied poly(N-isopropyl acrylamide) [1].