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目的研究我国结直肠癌发病模式近年来的变化。方法收集发表于1980年至1999年CJCR收录的中国核心期刊上发表的21篇中、英文文章。本研究总计10201例结直肠癌患者,根据发病时间,将他们分为80年代(1980～1989年)和90年代(1990～1999年)两组。结果80年代组有3420例患者,而90年代组有6781例患者。男、女比例80年代(1.50∶1)与90年代(1.26∶1)比较,差异有显著性意义(P<0.05)。原发肿瘤最常见的部位两组均在直肠,但直肠癌所占比例显著下降,横结肠和升结肠癌所占比例均显著升高,与之相比差异有显著性意义(P<0.001)。近侧结肠癌的比例增加(10.9%升至15.2%,P<0.001)。90年代组的DukesB期患者比例高于80年代组,而DukesD期患者所占比例明显减少(P<0.001)。结直肠腺癌的比例增高。结论中国结直肠癌的发病模式近年来变化很大,女性患者比例升高,发病部位逐渐右移。
Objective To study the changes of colorectal cancer incidence in recent years in China. Methods Twenty-one Chinese and English articles published in China’s core journals included in CJCR from 1980 to 1999 were collected. In this study, a total of 10,201 patients with colorectal cancer were divided into two groups according to the onset time: the 1980s (1980-1989) and the 1990s (1990-1999). Results There were 3420 patients in the 1980s and 6781 in the 1990s. The difference between men and women in the 80s (1.50: 1) and 90s (1.26: 1) was significant (P <0.05). The most common sites of primary tumors in the rectum, but the proportion of rectal cancer decreased significantly, the proportion of transverse colon and ascending colon cancer were significantly increased, compared with the difference was significant (P <0.001). The proportion of proximal colon cancer increased (10.9% to 15.2%, P <0.001). The proportion of patients with DukesB stage in the 90s was higher than that in the 80s, while the proportion of patients with DukesD stage was significantly reduced (P <0.001). The proportion of colorectal adenocarcinoma increased. Conclusion The incidence of colorectal cancer in China has changed greatly in recent years. The proportion of female patients increased and the incidence of the disease gradually shifted to the right.