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目的了解门诊高危人群和宫颈病变患者的人乳头状瘤病毒(HPV)感染的型别分布,探讨不同HPV亚型感染的致癌性。方法门诊就诊经组织病理学证实的宫颈病变患者165例,同时行HPV检测,分为宫颈炎60例,低级别病变(CIN1)51例;高级别病变(CIN2、CIN3)46例;宫颈癌(腺癌1例和鳞癌7例)8例。结果随着宫颈病变级别增高,HPV感染率逐渐上升;165例患者,HPV感染者92例,其中高级别宫颈病变及宫颈癌患者共47例,低级别病变患者有33例HPV阳性,两组感染高危型HPV的构成比有统计学意义(P<0.005)。结论不同宫颈病变感染HPV的优势亚型不同,其中HPV16亚型感染是高危型HPV中影响宫颈病变的发生、发展的重要因素。
Objective To understand the type distribution of human papillomavirus (HPV) infection in outpatients at high risk and cervical lesions and to explore the carcinogenicity of different HPV subtypes. Methods Outpatients were enrolled in the study. Totally 165 cases of cervical lesions confirmed by histopathology were examined by HPV at the same time. They were divided into 60 cases of cervicitis, 51 cases of low grade lesions (CIN1), 46 cases of high grade lesions (CIN2, CIN3) 1 case of adenocarcinoma and 7 cases of squamous cell carcinoma). Results The HPV infection rate gradually increased with the increase of cervical lesions. Among the 165 patients, 92 were HPV-infected, including 47 with high-grade cervical lesions and cervical cancer, 33 with HPV-positive in low-grade lesions and 2 with infection The proportions of high-risk HPV were statistically significant (P <0.005). Conclusions Different cervical lesions have different subtypes of HPV infection. HPV16 subtype infection is an important factor affecting the occurrence and development of cervical lesions in high-risk HPV.