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目的探讨以卡莫氟为主联合化疗治疗晚期消化道肿瘤的疗效。方法选取2011年11月—2013年11月在江苏省肿瘤医院诊断治疗的晚期消化道肿瘤患者60例,以口服卡莫氟为主同时辅以甲氧氯普胺预防消化道反应,疗程4~6周。采用WHO实体病疗效评价标准进行评定,并记录毒副作用发生情况。结果完全缓解(CR)率为5.00%,部分缓解(PR)率为53.33%,轻度缓解(MR)率为38.33%,无效2例。主要毒副作用为疲倦、尿频、腹泻、恶心、呕吐、白细胞计数减少等。结论以卡莫氟为主的化疗治疗晚期消化道肿瘤的疗效确切,对提高患者的生存质量有显著效果。
Objective To investigate the curative effect of carmofur-based combination chemotherapy for advanced gastrointestinal tumors. Methods Sixty patients with advanced gastrointestinal cancer who were diagnosed and treated in Cancer Hospital of Jiangsu Province from November 2011 to November 2013 were selected. Carmofovine was given orally and metoclopramide supplemented with prophylaxis of digestive tract reaction. The course of treatment was 4 ~ 6 weeks. The WHO evaluation of the efficacy of solid disease evaluation criteria for the assessment, and record the occurrence of toxic and side effects. Results The complete remission (CR) rate was 5.00%, partial remission (PR) rate was 53.33%, mild remission (MR) rate was 38.33%, and 2 cases were ineffective. The main side effects of toxicity, frequent urination, diarrhea, nausea, vomiting, reduced white blood cell count and so on. Conclusions Carmofluorine-based chemotherapy is effective in treating advanced gastrointestinal tumors and has a significant effect on improving the quality of life of patients.