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在美国黑色素瘤的发病率在迅速增长,因而黑色素瘤的肺转移也就成为一个更为常见现象和令人关注的课题。据报道25%的黑色素瘤可能发生肺转移,然而迄今为止,见诸文献的大都是一些例数较少的报道,难以反映全貌,为此作者分析了Duke大学癌症中心从1970～1990.期间共7654倒黑色素瘤(含有随访)的资料,其中945例发生了肺转移。采用单变量与多变量分析方法,借以确定黑色素瘤发生肺转移的危险因素、肺切除术在治疗黑色素瘤肺转移中的地位以及影响肺转移患者存活的因素。结果发现:(1)在诊断黑色素瘤后3、5、10和20年的发生肺转移的比率分别为0.9,0.13,0.19和0.30;945例肺转移的1年、3年和5年生存率分别为30%,9%和4%。(2)以下因素增加黑色素瘤发生肺转移的危险:①男性、黑
The incidence of melanoma in the United States is rapidly increasing, and the lung metastasis of melanoma has become a more common phenomenon and a concern. It has been reported that 25% of melanomas may have lung metastases. However, to date, most of the literature has been reported in a few cases and it is difficult to reflect the whole picture. To this end, the author analyzed the Duke University Cancer Center from 1970 to 1990. The 7654 melanoma (with follow-up) data was available, of which 945 had lung metastases. Univariate and multivariate analyses were used to identify risk factors for melanoma lung metastasis, the role of pneumonectomy in the treatment of melanoma lung metastases, and factors affecting the survival of patients with lung metastases. Findings: (1) The rates of lung metastases at 3, 5, 10, and 20 years after diagnosis of melanoma were 0.9, 0.13, 0.19, and 0.30, respectively; 1-, 3-, and 5-year survival rates of 945 lung metastases It is 30%, 9% and 4% respectively. (2) The following factors increase the risk of lung metastasis in melanoma: 1 Male, black