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目的:探究HP感染与胃癌患者病理特征性改变的相关性。方法:选取我院消化内科收治并确诊为胃癌的患者50例,作为胃癌组;确诊为慢性浅表性胃炎的患者50例,作为胃炎组;选取同期进行健康体检未发现胃部异常的患者50例,作为对照组。对三组患者进行快速尿素氮试验、13C尿素呼气试验以及血清抗HPCag A等检查,比较患者HP感染等情况。结果:胃癌组及胃炎组患者HP感染阳性率及抗HPCag A阳性率显著高于对照组,且胃癌组较胃炎组明显增高,差异有统计学意义(P<0.05)。胃癌早期及进展期患者HP感染率高于对照组,差异有统计学意义(P<0.05)。胃癌组患者非贲门部HP感染率显著高于贲门部及对照组,差异有统计学意义(P<0.05)。结论:HP感染是导致胃癌的主要因素,明确HP感染与胃癌病理分期及病变部位的相关性对胃癌的治疗及预防有重要的临床意义。
Objective: To investigate the correlation between HP infection and pathological changes of gastric cancer. Methods: Fifty patients with gastric cancer who were diagnosed as gastric cancer and 50 patients with chronic superficial gastritis diagnosed as gastritis were enrolled in this study. Fifty patients with gastric abnormalities in the same period Example, as a control group. Three groups of patients with rapid urea nitrogen test, 13C urea breath test and serum anti-HPCag A and other tests to compare patients with HP infection and so on. Results: The positive rate of HP infection and the positive rate of anti-HPCag A in gastric cancer group and gastritis group were significantly higher than those in the control group, and the gastric cancer group was significantly higher than the gastritis group, the difference was statistically significant (P <0.05). The prevalence of HP infection in patients with early and advanced gastric cancer was higher than that in the control group, with significant difference (P <0.05). The HP infection rate of non-cardia in gastric cancer patients was significantly higher than that in cardia and control groups, with significant difference (P <0.05). Conclusion: HP infection is the main factor leading to gastric cancer. To clarify the correlation between HP infection and pathological stage and location of gastric cancer has important clinical significance for the treatment and prevention of gastric cancer.