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作者报告荷兰Utrecht大学放射治疗科从1976年1月开始进行的30例非何杰金氏淋巴瘤全身照射(TBI)的结果。其中11例以前接受过局部放疗或化疗,19例未曾治疗。作者复查了最初诊断的淋巴结活检切片,按Rappaport(1966)分类和Ann Arbor系统分期方法。依临床检查、胸片,淋巴造影,骨髓活检及生化检查,6例属Ⅲ期,24例属Ⅳ期。有些病人做了剖腹术。放疗时病人处于直立位,用6Mev直线加速器,靶皮距600公分进行全身照射,一周三次,每次中平面10拉得,最大总量300拉得。毒性反应:主要是血液学的抑制,未观察到呕吐、腹泻,皮肤改变及脱发;因病变产生症状者,在治疗期间发现症状明显缓解。作者的印象是,由TBI造成的血液学抑制为暂时性、中等程度抑制(白细胞不低
The authors report the results of 30 cases of non-Hodgkin’s lymphoma (TBI) performed by the Department of Radiotherapy at Utrecht University in the Netherlands from January 1976. Eleven of them had previously received local radiotherapy or chemotherapy, and 19 had not been treated. The authors reviewed the initially diagnosed lymph node biopsies, according to the Rappaport (1966) classification and the Ann Arbor system staging method. According to clinical examination, chest radiograph, lymphography, bone marrow biopsy and biochemical examination, 6 cases belonged to stage III and 24 cases belonged to stage IV. Some patients have laparotomy. During radiotherapy, the patient was in an upright position, using a 6Mev linear accelerator with a target skin distance of 600 cm for full body irradiation, three times a week, each time the median plane was pulled 10, and the maximum total 300 pulled. Toxic reactions: mainly hematological inhibition, vomiting, diarrhea, skin changes and hair loss were not observed, and symptoms were significantly relieved during treatment. The author’s impression is that the hematological suppression caused by TBI is temporary, moderately suppressed (white blood cells are not low