目的：探讨度洛西汀联合小剂量奥氮平治疗更年期抑郁症伴激越症状患者的疗效和安全性。方法将96例更年期抑郁症伴激越症状患者按随机数字表法分为两组，每组48例，均口服度洛西汀治疗，研究组在此基础上联合小剂量奥氮平治疗，观察6周。治疗前后采用汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。结果治疗第2周末起两组汉密顿抑郁量表总分及激越因子分均较治疗前显著下降（P＜0．01），但研究组治疗第2周、4周末汉密顿抑郁量表总分及激越因子分显著低于对照组（ P＜0．05或0．01）；治疗第6周末研究组总有效率为85．4％，对照组为66．7％，研究组总有效率显著高于对照组（ P＜0．05）。两组不良反应均较轻微，发生率比较差异无显著性（P＞0．05）。结论度洛西汀联合小剂量奥氮平治疗更年期抑郁症伴激越症状具有协同增效作用，起效快，疗效显著，安全性高，优于单用度洛西汀治疗。“,”Objective To explore the efficacy and safety of duloxetine combined with small dose of olanza‐pine in the treatment of involutional depression (ID) with agitated symptoms .Methods Ninety‐six ID pa‐tients with agitated symptoms were randomly divided into two groups of 48 ones each ,both groups took o‐rally duloxeline ,and on this basis research group was plus small dose of olanzapine for 6 weeks .Efficacies were assessed with the Hamilton Depression Scale (HAMD) before and after treatment and adverse reac‐tions with the Treatment Emergent Symptom Scale (TESS) .Results Since the end of the 2nd week the to‐tal and agitation scores of the HAMD of both groups lowered more significantly compared with pretreat‐ment (P<0 .01) ,those were significantly lower in research than in control group at the ends of the 2ndand 4th week (P<0 .05 or 0 .01);at the end of the 6th week the total effective rate was respectively 8 .4% in re‐search and 66 .7% in control group ,the former significantly higher than the latter (P0 .05) .Con‐clusion Duloxetine combined with small dose of olanzapine has a synergism ,takes effect more rapidly , has an evident effect and higher safety compared with single duloxetine in the treatment of involutional de‐pression with agitated symptoms .