HDAC相关论文
恶性肿瘤是一种涉及多个基因,发病机理高度复杂的疾病,目前临床使用的单靶点药物不能完全杀灭肿瘤细胞而且容易产生耐药性。组蛋白......
癌症是当前危害人类健康和生命的重大疾病之一,2020年全球范围内共有1929万癌症新增病例和996万癌症死亡病例,我国癌症新增及死亡......
棉花是重要的纤维和油料作物,黄萎病是由大丽轮枝菌引起的一种通过土壤传播的维管束病害,严重妨碍了棉花的生产。栽培棉种对病虫害......
异染色质在真核生物基因组中发挥了重要功能,通常情况下细胞中特定的异染色质因子协同作用,共同参与调节染色体组装、维持着丝粒功......
Design,synthesis and antitumor evaluations of nucleoside base hydroxamic acid derivatives as DNMT an
DNA methyltransferase (DNMT) and histone deacetylase (HDAC) are well recognized epigenetic targets for discovery of anti......
BRD4 inhibitor and HDAC inhibitor synergistically inhibit the proliferation of gallbladder cancer in
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CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis
目的 Evading TGF-β-mediated growth inhibition is often associated with tumorigenesis in liver,including hepatocellular ......
Entinostat-attenuated DNA repair protein MGMT plays a crucially synergistic role in temozolomide-inj
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Inhibitory mechanisms of T7, a novel histone deacetylase inhibitor, on lipopolysaccharide-induced cy
Aim: Gram-negative bacterial sepsis remains a common life-threatening event.Lipopolysaccharide (LPS), a component of the......
Aim: The role of histone deacetylases (HDACs) and the potential of these enzymes as therapeutic targets for cancer is an......
Histone deacetylase inhibition attenuates development of hypertension through mineralocorticoid rece
Background: Inhibition of histone deacetylases (HDAC) results in attenuated development of hypertension in DOCA-induced ......
Novel Histone Deacetylase(HDAC)Inhibitors Equipped with Phenylsulfonylfuroxan Module as Nitric Oxide
Based on the strategy of “multifunctional drugs”,a novel series of phenylsulfonylfuroxan-based hydroxamates with histo......
组蛋白去乙酰化酶(HDAC)在肿瘤的发生发展过程当中起着十分重要的作用，近年来，已有多个 HDAC 抑制剂被批准上市。但随着HDAC 抑制剂......
目的：HACE1是位于6q21染色体上的潜在肿瘤抑制基因，通过介导细胞自噬、Rac1的泛素化等多种作用机制参与肿瘤细胞的生长和凋亡调控.HA......
LH regulation of the EGF network is essential for oocytes maturation and the ovulatory process.The mechanisms underlying......
Objective To investigate the change patterns of Histone 3 lysine 9 acetylation (H3K9ac) and the expression profile of hi......
The in Silico Molecular Interaction of Organoboron Compounds as Curative Measure toward Cervical Can
The hazard of cervical cancer is a real threat in the developing countries.Rational drug design technology has successfu......
目的 研究SNOH-3/15两种药物体外抗肺癌的活性,并探讨其作用机制。方法 采用MTT法观察SNOH-3/15对NCI-H1299和A549细胞增殖的抑制......
HBO1,a member of the MYST family histone acetyltransferases(HATs),is required for global acetylation of H3K14 and embryo......
Aim: Histone deacetylases (HDACs) are often found over-expressed in human cancers, including colorectal cancer, and has ......
The correlation of DNMT and HDAC expression with clinicopathological features in Chinese women spora
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HDACs play important roles in regulating various physiological and pathological processes.Developing fluorescent probes ......
Genome-edited human induced pluripotent stem cells(iPSCs)hold great promise for therapeutic applications.However,low edi......
CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis
Evading TGF-β-mediated growth inhibition is often associated with tumorigenesis in liver,including hepatocellular c......
The anticancer therapies with the joint treatment of a histone deacetylase(HDAC) inhibitor and a DNA-damaging approach a......
组蛋白去乙酰化酶抑制剂(histone deceatylase inhibitor,HDACi)是一类抑制组蛋白去乙酰化的有机化合物,通过改变组蛋白乙酰化程度......
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泛素-蛋白酶体系统(ubiquitin-proteasome system,UPS)降解蛋白质的过程是维持细胞稳态的重要调节机制之一.在骨骼肌萎缩过程中,UP......
目的:探讨内源性肾上腺糖皮质激素时脂多糖(lipopolysaccharide,LPS)诱导大鼠血管炎症因子IL-6、IL-β、IL-10表达、促炎转录因子N......
目的:HDACi对卵巢癌细胞具有明显杀伤作用。但以往临床实验观察到HDACi单药方案用于卵巢癌时效果不明显。其中一个重要原因是目前......
组蛋白去乙酰化酶(HDACs)被证实与多种蛋白的乙酰基移除有关,并介导了大量生物学反应过程。HDAC3是HDACs家族I类一员,在生物体内广......
研究背景及意义:脑卒中是一种多因素疾病,环境因素和遗传因素的交互作用在脑卒中发病中具有重要的作用。全球每年约有1500万脑卒中......
组蛋白去乙酰化是一种与基因转录抑制相关的重要的表观遗传修饰,其功能主要由组蛋白去乙酰化酶(HDACs)家族来行使。目前,已报导的H......
背景:蛋白酶活化受体4(protease-activated receptors 4,PAR4)为G蛋白偶联受体,在血栓形成、炎症反应、血管活性、免疫系统功能、......
目的分析组蛋白去乙酰化酶(HDAC)抑制剂丙戊酸(Valproic acid,VPA)对小鼠T细胞亚群IL-2、IFN-γ和IL-6表达的影响,探讨其抗炎免疫......
通过计算机模拟的对接过程研究,发现了MS-275——一种苯甲酰胺类的组蛋白去乙酰酶(HDAC)抑制剂与酶的可能的全新结合方式。这种结......
曲古抑菌素A(trichostatin A,TSA)作为组蛋白去乙酰化酶抑制剂(histone deacetylase inhibitor,HDACi),是近年来发现的一类新型抗......
Sphingosine-1-phosphate(S1P) is a bioactive lipid messenger in the cells that regulate gene expression and NF-κB signal......
本文以肿瘤为研究对象，提出了将组蛋白去乙酞化酶抑制剂应用到肿瘤的治疗当中，指出HDAC抑制剂作为新型的非细胞毒类抗肿瘤药物，通过调......
会议
Clinical and translational studies of HDAC inhibitors in cutaneous T-cell lymphomas-美国得州大学MD安得森癌症中心之
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目的 设计合成一系列1,4-二烯-3-酮苯甲酰胺类(组蛋白去乙酰化酶HDACs)抑制剂,并评价其对A549、Hep3B、PANC-1肿瘤细胞的体外抗增......
组蛋白去乙酰化酶抑制剂(histone deceatylase inhibitor,HDACi)是一类抑制组蛋白去乙酰化的有机化合物,通过改变组蛋白乙酰化程度......
手机屏幕越来越大，平板电脑屏幕越来越小，两者似乎已经成为一种趋势。在苹果推出iPad mini之后，国内也很快涌现出一批7英寸到8英寸的......
心力衰竭(HF)是多种心血管疾病的最终临床转归,其中心脏病理性重构是HF重要的病理生理基础。目前尚缺乏针对心脏病理性重构的特异......
,Histone deacetylase inhibitors attenuate P-algA1-induced cell proliferation and extracellular matri
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,Marine-derived chromopeptide A, a novel class Ⅰ HDAC inhibitor, suppresses human prostate cancer ce
Histone deacetylases (HDACs),especially HDAC1,2,3 and 4,are abundantly expressed and over-activated in prostate cancer t......
,CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in
Pancreatic adenocarcinoma is a highly malignant cancer that often involves a deregulation of c-Myc.It has been shown tha......
