Deacetylase相关论文
Lysine acetylation is a reversible posttranslational modification(PTM)of proteins regulated by lysine acetylases(KATs)an......
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The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral
Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyc......
Primary malignant brain tumors are a major cause of morbidity and mortality in both adults and children,with a dismal pr......
Characterization and functional analysis of chitinase family genes involved in nymph-adult transitio
Chitinase degrades chitin in the old epidermis or peritrophic matrix of insects,which ensures normal development and met......
Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in
Amyotrophic lateral sclerosis(ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor ne......
SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that p......
The anticancer therapies with the joint treatment of a histone deacetylase(HDAC) inhibitor and a DNA-damaging approach a......
Determination and stress studies on YK-1101,a potential histone deacetylase,by HPLC-UV and HPLC-TOF/
YK-1101,with its structure as S-((E)-4-((7S,10S,Z)-4-ethylidene-7-isopropyl-2,5,8,12tetraoxo-9-oxa-16-thia-3,6,13,18-tet......
Objective: To explore the protection and molecular mechanism of histone deacetylase inhibitors(HDACIs) on the spleen of ......
Sirtuins(SIRTs) are nicotinamide adenine dinucleotide(NAD~+)-dependent protein deacetylases,which regulate important bio......
AIM:To investigate the effect of histone acetylation onregulation of p21~(WAF1) gene expression in human colon cancerce......
Aim:To investigate curcumin(diferuloylmethane)induced apoptosis and its mo-lecular mechanism of action in B-NHL cell li......
目的：本研究旨在探讨Resveratrol对人T 淋巴细胞活化的影响及其分子机制。方法在体外使用Resveratrol处理人外周血T 细胞，并给予抗人......
沉默信息调节因子2相关酶1（Sirt1）是一种依赖于烟酰胺腺嘌呤二核苷酸的Ⅲ类组蛋白脱乙酰化酶，为哺乳动物Sirtuin家族成员之一。 Sirt1......
Parkinson’s disease(PD)is the second most common neurodegenerative disorder and is characterized by its progressive cou......
Inhibition of histone deacetylase for the treatment of biliary tract cancer:A new effective pharmaco
AIM:TO investigate in vitro and in vivo therapeutic effects of histone deacetylase inhibitors NVP-LAQ824 and NVP-LBH589 ......
Objective To investigate the therapeutic effects of givinostat,a histone deacetylase inhibitor(HDACI),on the development......
OBJECTIVE: The roots of Chlorophytum borivilanum are used in traditional medicine for the treatment of arthritis and inf......
Background and objective:Liver regeneration is a complex process regulated by a group of genetic and epigenetic factors.......
Background Histone deacetylase inhibitors(HDACIs)have been reported to induce apoptosis in cancer cells.Theeffects of t......
AIM: To investigate the antiproliferative effect of the histone deacetylase (HDAC) inhibitor MS-275 on cholangiocarcinom......
目的综述组蛋白去乙酰化酶(histone deacetylase,HDAC)抑制剂(HDACi)在非肿瘤领域的研究进展。方法收集近15年的HDAC抑制剂在非肿......
AIM: To explore the effect of histone deacetylase inhibitor, trichostatin A (TSA) on the growth of biliary tract cancer ......
AIM: To explore the effect of trichostatin A (TSA) on apoptosis and acetylated histone H3 levels in gastric cancer cell ......
Design, synthesis, and biological evaluation of N-hydroxycinnamamide/salicylic acid hybrids as histo
Novel histone deacetylase(HDAC) inhibitors 9a–l were designed and synthesized by coupling the carboxyl group of salicyl......
Regulation of demethylation and re-expression of RASSF1A gene in gastric cancer cell lines by combin
AIM: To investigate the changes of methylation state and expression of RASSF1A gene in human gastric cancer cell lines S......
AIM:To evaluate the antitumoral effect of combined inhibitors of angiogenesis and histone deacetylases in an experimenta......
Pancreatic cancer,although not very frequent,has an exceptionally high mortality rate,making it one of the most common c......
Pancreatic cancer is one of the most aggressive human cancers,with more than 200 000 deaths worldwide every year.Despite......
DNA双链断裂(double strand breaks,DSBs)对细胞生存是致命的.细胞内非同源末端连接(NHEJ)、重组修复(HDR)、单链退火修复(SSA)和......
Histone deacetylase(HDAC) inhibitors, which represent a structurally diverse group of molecules, have emerged as a novel......
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A phase Ⅰ trial of an oral subtype-selective histone deacetylase inhibitor, chidamide, in combinatio
Objective: This phase Ⅰ study was to evaluate safety, maximum tolerated dose, pharmacokinetics and preliminary antitumo......
INTRODUCTIONrnAccording to the demographics,the world population over 60 years will double from 605 million to 2 billion......
目的探讨沉默信息调节因子2-相关酶3(SIRT 3)对肾透明细胞癌细胞系786-O中锰型超氧化物歧化酶(MnSOD)的去乙酰化作用及其对786-O细......
组蛋白乙酰化修饰是真核细胞基因表达的一种重要调控方式,组蛋白去乙酰化酶作为组蛋白去乙酰化的关键调节酶,在包括肝癌在内的许多......
Inhibitory Effect of Histone Deacetylase Inhibitor on the Proliferation of Leukemia Cells and Its An
The aim of this study was to explore the inhibitory effect of histone deacetylase inhibitor (HDACI) on the proliferation......
Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitor
AIM:To clarify whether histone deacetylase inhibitors histone deacetylase inhibitors(HDACIs)can sensitize hepatocellular......
自噬现象广泛存在于真核细胞中,是细胞的一种自我保护机制。这类分解代谢过程发生在细胞内,进化上具有高度保守性,在多种疾病及生......
白藜芦醇作为一种天然多酚类物质在很多植物中都存在,然而白藜芦醇的一些属性和作用也使得它广泛运用于动物实验中。本研究主要探......
Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with c
AIM： To investigate the growth effects of 4-phenyl butyric acid （PBA） on human gastric carcinoma cells and their mechanisms......
Pancreatic cancer,although not very frequent,has an exceptionally high mortality rate,making it one of the most common c......
Pancreatic cancer is one of the most aggressive human cancers,with more than 200 000 deaths worldwide every year.Despite......
lncRNA-SNHG15 accelerates the development of hepatocellular carcinoma by targeting miR-490-3p/histon
BACKGROUND Hepatocellular carcinoma(HCC)has become a great threat for people’s health.Many long noncoding RNAs are invo......
目的：探讨组蛋白脱乙酰化酶（HDAC）抑制剂丙戊酸钠（valproic acid，VPA）逆转AML1-ETO融合蛋白转录抑制作用。方法：VPA处理t（8；21）急性白血病细......
以海洋烟曲霉菌为出发菌，在适宜的发酵条件下进行培养，提取代谢产物并检测其对白色念珠菌抑菌性．分别以硫酸铵、石油醚、乙酸乙酯为萃......
目的构建结核分枝杆菌去乙酰化酶2（Sir2）原核表达载体,并进行表达纯化及酶学研究。方法以结核分枝杆菌H37Rv基因组DNA为模板,聚合酶......
Most therapeutic protocols for child cancers use cytotoxic agents which have a narrow therapeutic index,and resulting in......
Effects of acute doxorubicin treatment on hepatic proteome lysine acetylation status and the apoptot
AIM: To determine if doxorubicin(Dox) alters hepatic proteome acetylation status and if acetylation status was associate......
