NNRTIS相关论文
Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs:Design, synthesis and bio
Drug resistance remains to be a serious problem with type I human immunodeficiency virus (HIV-1) non-nucleoside reverse ......
艾滋病（AIDS）即获得性免疫缺陷综合征（Acquired immunodeficiency syndrome）,是由人类免疫缺陷病毒（HIV）感染所致的一种全球性流行疾病。......
[目的]艾滋病,又称获得性免疫缺陷综合征（Acquired immunodeficiency syndrome,AIDS）,它形成的原因是人类免疫缺陷病毒（Human immunod......
Benzophenone derivatives(BPs),such as GW678248 and GW4511,have been reported as a class of HIV-1 NNRTIs with excellent p......
Discovery of etravirine-JLJ506 hybrids as potent HIV-1 NNRTIs through structure-guided molecular hyb
The long-term usage of HIV-1 non-nucleoside reverse transcriptase inhibitors(NNRTIs)usually leads to rapid emergence of ......
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with novel structures,a series of novel imida......
Guided by crystal structures of HIV-1 RT/diarylpyrimidine(DAPY)complex,molecular modeling studies and our previous effor......
Design,synthesis and biological evaluation of novel fused heterocyclic derivatives as potent HIV-1 N
In current anti-HIV drug research field,diarylpyrimidines(DAPYs)represents the most potent and promising NNRTIs class fo......
A series of novel diarylpyrimidine with a halogen substituent on the methylene linker between wing I and the central pyr......
Design,synthesis,and biological investigation of new C6-rigid S-DABOs as Non-nucleoside HIV-1 revers
A series of C6-rigid S-DABO analogs featured with a substituted benzoyl group at C6 position of the pyrimidine ring has ......
Synthesis and Biological Evaluation of New Conformationally Restricted S-DABO Hybrids as Non-nucleos
A series of conformationally restricted S-DABO hybrids combined the structural features of α-methyl-S-DABOs and CN-S-DA......
Guided by crystal structures of HIV-1 RT/DAPY complex,molecular modeling studies and our previous efforts,series of nove......
PT-PP44:Influence of AMBER Force Fields on Particular Interaction Energy of HIV-1 Reverse Transcript
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Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrim
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with diverse structures,a series of novel S-D......
Two series of sulfur-containing diarylbenzopyrimidines are designed by the fragment combination of a thioacetamide with ......
Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrim
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with diverse structures, a series of novel S-......
艾滋病是由人体免疫缺陷病毒(简称HIV病毒)的感染而引起的疾病,它会破坏人体自身的免疫系统,导致人体对外界环境缺乏免疫力,从而容......
本文报道了4,6-二苄基-3-氰基-2(1H)-吡啶酮的合成方法。合成了重要中间体3-氧代-4-苯基丁酸乙酯,为合成不同的6位取代的吡啶酮类......
建立9种临床常见的对非核苷类逆转录酶抑制剂(non-nucleoside reverse-transcriptase inhibitors,NNRTIs)耐药型HIV-1重组病毒药理......
本文报道了4,6-二苄基-3-氰基-2(1H)-吡啶酮的合成方法.合成了重要中间体3-氧代-4-苯基丁酸乙酯,为合成不同的6位取代的吡啶酮类化......
随着艾滋病病毒在全球范围内的迅速传播和耐药性的日益严重,开发新型有效的抗艾滋病药物显得尤为迫切.非核苷逆转录酶抑制剂(NNRTI......
HIV-1非核苷逆转录酶抑制剂(NNRTIs)是高效抗逆转录病毒疗法(HAART)的重要组成部分.但是,NNRTIs仍存在交叉耐药性、药动学性质不佳......
Receptor-based Molecular Designs of DABO Derivatives as HIV-1 Nonnucleoside Reverse Transcriptase In
本文通过对荣华二采区10...
,Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted t
In this report,a series of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives were designed to explore ......
,Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-
A series of 2-(((5-akly/aryl-lH-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones were synthes......
,Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazin
In order to improve the positional adaptability of our previously reported naphthyl diaryltria-zines (NP-DATAs),synthesi......
Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS),and non-......
艾滋病,全名为“获得性免疫缺陷综合症”(Acquired immunodeficiencysyndrome,AIDS),是由人类免疫缺陷病毒(Human immumodeficienc......
目的 探讨以PIs或NNRTIs为主方案治疗HIV/HCV合并感染的患者比较其安全性.为临床治疗药物的选择提供依据.方法 2007~2008年分别在......
期刊
随着高效抗逆转录病毒治疗(HAART)的临床应用,患者的生存期显著延长了,抗药性成为日渐突出的问题.NNRTIs的抗药屏障较弱,一类药物......
Receptor-based Molecular Designs of DABO Derivatives as HIV-1 Nonnucleoside Reverse Transcriptase In
A series of 46 dihydro-alkoxy-benzyl-oxopyrimidines (DABOs), a class of highly potent non-nucleoside reverse transcripta......
非核苷类逆转录酶抑制剂（NNRTIs）是抗艾滋病毒的一线药物,具有低毒高效的显著疗效。但其溶水性差、生物利用度低等缺点限制了NNRTIs......
基于非核苷类逆转录酶抑制剂DABO类似物的构效关系，设计了4个新的DABO类化合物，并采用微波催化的方法进行了合成，最后通过^1HNMR，^13CN......
以对硝基苯胺为原料，经重氮化、成腙、环合、水解等四个步骤得到抗艾滋病药物地拉韦啶的关键中间体5-硝基-1H-吲哚-2-羧酸，产物结构......
目的探讨以蛋白酶抑制剂（PIs）或非核苷类反转录酶抑制剂（NNRTIs）为主方案治疗丙型肝炎病毒（HCV）／人类免疫缺陷病毒（HIV）合并感染的患者，比较......
目的探讨以蛋白酶抑制剂（PIs）或非核苷类反转录酶抑制剂（NNRTIs）为主方案治疗丙型肝炎病毒（HCV）／人类免疫缺陷病毒（HIV）合并感染的患者，比较......
Computational modeling studies on anti-HIV-1 non-nucleoside reverse transcriptase inhibition by dihy
For the first time we report quantitative structure activity relationship (QSAR) studies based on Kier-Hall Electrotopol......
目的探讨以PIs或NNRTIs为主方案治疗HIV／HCV合并感染的患者比较其安全性。为临床治疗药物的选择提供依据。方法2007～2008年分别在上......
Regioselective synthesis and anti-HIV activity of the novel 2- and 4-substituted pyrazolo[4,5-e] [ 1
The new regioisomer 7-methyl-pyrazolo[4,5-e][1,2,4]thiadiazine nucleus (5) was synthesized, and its novel mono-N2- or N4......
艾滋病(AIDS)是获得性免疫缺陷综合征的简称,是由人类免疫缺陷病毒(HIV)引起的一种严重传染病(乙类)。艾滋病主要通过性接触及输血......
随着高效联合抗逆转录病毒治疗(HAART)的进展,副作用、耐药性等问题日益突出,影响了持续治疗.目前正在研究许多新的药物,它们具有......
<正>艾滋病(acquired immune deficiency syndrome,AIDS)是由人类免疫缺陷病毒(human immunodeficiency virus,HIV)引起的一种传染......
艾滋病(AIDS)是由人类免疫缺陷病毒(HIV)感染引起的全球重大流行性传染病。据世界卫生组织(WHO)的数据报道,截至2018年底,因感染艾......
人类免疫缺陷病毒(HIV)是导致传染性疾病获得性免疫缺陷综合征(艾滋病,AIDS)的病原体。在HIV复制循环中,其自身的多功能性蛋白逆转......
<正>联合抗逆转录病毒疗法(combination antiretroviral therapy,cART)的兴起和发展改变了艾滋病的预后,控制了人类免疫缺陷病毒(h......
肝脏独特的超微结构和血液供应有助于肝脏发挥代谢、合成、分解排泄等功能,但也使肝脏容易受到各种病毒、细菌、真菌等感染。人类......
高效抗逆转录病毒疗法(highly active antiretroviral thera-py,HAART)的应用显著地降低了AIDS相关的发病率及死亡率[1].可是多达2......
<正>人类免疫缺陷病毒(Human immunodeficiency virus,HIV)是一种感染人类免疫系统细胞的慢病毒(Lentivirus)。位于T淋巴细胞上的C......
