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Background: For the patients with chronic heart failure (CHF) or the heart-wounded, the amounts ofANP, BNP and CNP are suddenly increased in plasma.Then ANP, BNP and CNP play the important role to keep the metabolic system working.Clinical experience shows that the infusion ofexogenetic NPs into blood is a good way.Nevertheless, how to control the dose is a challenge.Comparably, a novel way using the endogenetic material to promote the reserves of NPs in blood will be proposed if we note that reserves ofANP, BNP and CNP depend on: (1) the natriuretic peptide protein A (NPPA), the natriuretic peptide protein B (NPPB) and the natriuretic peptide protein C (NPPC)); (2) the activity of the hydrolyzing enzymes corin, forin and the neutral endopeptidase (NEP); and (3) the natriuretic peptide receptors (NPRs).To increase the reserves ofANP, BNP and CNP, we have two things to do.(1) Promoting the productions ofNNPA, NNPB and NNPC; (2) Minimizing the consumption ofANP, BNP and CNP.Methods: Within the small network consisted of the NPPs, eorin, forin, NEP, NPR-A, NPR-B and NPR-C, we use the HuMiTar to get these miRs which modulate down that expression profiles of NEP and NPRs but do not interfere with NPPs and hydrolyzing enzymes; as well as, to get these miRs which may modulate down the expression profiles of NPPs and hydrolyzing enzymes but do not interfere with NEP and NPRs.Of course, all of these miRs we choose do not interfere with all regular proteins in human body heavily.Conclusion: If we use the heart tissue of pig or bovine as the food to promote the productions of NPRA, NPRB and NPPC in natural way, and use the miRs to modulate down the expression profiles of NPR3 and PHEX directly, then we will get more reserves ofANP, BNP and CNP.This is an operable Rx.