近年来的研究结果说明细胞的分裂、死亡及分化与致癌作用间存在密切关系,本文重点讨论细胞内钙离子([Ca~(2+)]i)失调在细胞损伤及致癌过程中的作用。细胞钙的调节作用细胞液内(Ca~(2+))i 水平很低,调节范围很窄(～10~(-7)～10~(-8)M),它受到浓度很高的细胞外钙离子((Ca~(2+)]e)的调节。[Ca~(2+)]e 通过许多通道进入胞液,细胞内调节[Ca~(2+)]i 的缓冲体系主 In recent years, the results show that there is a close relationship between cell division, death and differentiation and carcinogenesis. This article focuses on the role of intracellular calcium ([Ca ~ (2 +)] i) imbalance in cell injury and carcinogenesis. Modulation of cellular calcium Low intracellular Ca (2 +) i level and narrow regulatory range (~ 10 ~ (-7) ~ 10 ~ (-8) M), it is affected by high concentration of cells (Ca2 +)] e. [Ca2 +] e enters the cytosol through many channels and intracellularly modulates the buffer system of [Ca2 +] i