论文部分内容阅读
目的:探讨乳腺癌患者外周血CK19的表达及其临床意义。方法:采用流式细胞术检测50例乳腺癌患者化疗前后外周血CK19的表达;22例乳腺良性病变患者及健康人20名作为正常对照。结果:乳腺癌患者外周血CK19的表达与正常对照组相比较,差异有统计学意义,P<0.05。肿瘤的大小、腋窝淋巴结及TNM分期与外周血CK19的表达有关(P<0.05)。结论:应用流式细胞术检测外周血CK19的表达可作为临床监测、指导辅助治疗和判断预后的参考指标。
Objective: To investigate the expression of CK19 in peripheral blood of patients with breast cancer and its clinical significance. Methods: The expression of CK19 in peripheral blood of 50 patients with breast cancer before and after chemotherapy was detected by flow cytometry. Twenty-two patients with benign breast disease and 20 healthy individuals were selected as normal control. Results: The expression of CK19 in peripheral blood of breast cancer patients was significantly higher than that of the control group (P <0.05). The size of tumor, axillary lymph node and TNM staging correlated with the expression of CK19 in peripheral blood (P <0.05). Conclusion: The detection of CK19 expression in peripheral blood by flow cytometry can be used as a reference index for clinical monitoring, guiding the adjuvant therapy and prognosis.