论文部分内容阅读
目的了解孕期暴露PM2.5对新生儿生长发育的影响。方法于2012年9月—2013年8月,测定哈尔滨市郊区和哈尔滨市区大气PM2.5浓度,2013年4月—8月随机从市区和郊区抽取分娩的孕妇-新生儿各50对,并收集孕妇和新生儿的相关资料,检测新生儿脐静脉血清中铅、锰、铬水平及胰岛素样生长因子1(IGF-1)、IGF-2水平。结果与郊区相比,市区大气PM2.5浓度、新生儿血清中铅、锰、铬水平均较高;IGF-1、IGF-2浓度较低,差异有统计学意义(P<0.05)。简单线性回归分析结果表明,对新生儿身长具有抑制性作用的因素包括母亲孕期被动吸烟、家庭装修、室内燃煤、新生儿高脐血铅水平,具有促进作用的因素包括高IGF-1水平和高IGF-2水平;对新生儿体重具有抑制性作用的因素包括新生儿高脐血铅水平和高脐血铬水平,具有促进作用的因素为高IGF-1水平。多重线性逐步回归分析结果表明,孕期居住在大气PM2.5较高地区、孕期被动吸烟、新生儿高脐血铅水平是影响新生儿身长的危险因素,高IGF-1水平和高IGF-2水平是影响新生儿身长的保护因素;未发现上述影响因素与体重的关联。结论孕期PM2.5暴露可能通过抑制新生儿体内IGF-1、IGF-2水平,从而抑制新生儿身长。
Objective To understand the impact of PM2.5 exposure during pregnancy on newborn growth and development. Methods From September 2012 to August 2013, the concentrations of PM2.5 in the suburbs of Harbin and Harbin were measured. 50 pregnant and newborns were randomly selected from urban and suburban areas from April to August in 2013, Maternal and neonatal data were collected to detect levels of lead, manganese and chromium, and insulin-like growth factor 1 (IGF-1) and IGF-2 levels in neonates with umbilical venous blood. Results Compared with the suburbs, the concentration of PM2.5 in the urban area and the levels of serum lead, manganese and chromium in neonates were higher than those in the suburbs. The concentrations of IGF-1 and IGF-2 were lower (P <0.05). Simple linear regression analysis showed that the factors that have an inhibitory effect on the length of the newborn include passive smoking in the mother’s pregnancy, home decoration, indoor coal combustion, and high umbilical cord blood lead levels in newborns. The promoting factors include high IGF-1 level and High IGF-2 levels; factors that have an inhibitory effect on neonatal body weight include high cord blood levels of neonates with high cord blood levels and high cord blood levels of chromium, with a contributing factor of high IGF-1 levels. Multiple linear stepwise regression analysis showed that pregnant women living in higher atmospheric PM2.5 area during pregnancy passive smoking, neonatal high cord blood lead levels are risk factors affecting the length of newborns, high IGF-1 levels and high IGF-2 levels Is a protective factor affecting the length of newborns; found no association between these factors and weight. Conclusion PM2.5 during pregnancy may inhibit the growth of neonates by inhibiting the levels of IGF-1 and IGF-2 in neonates.