感染中毒症和急性肺损伤时机体强烈的炎症反应可诱导凝血 抗凝 纤溶异常。已发现抗凝蛋白活化蛋白C、抗凝血酶 Ⅲ和组织因子途径抑制物在炎症反应中起重要调节作用。应用外源性抗凝物质替代治疗 ,可以改善有关疾病预后 (活化蛋白C)或临床表现 (抗凝血酶 Ⅲ和组织因子途径抑制物 ) ,为感染中毒症及相关疾病的治疗提出了新的方向 Infection with acute lung injury and acute inflammatory injury can induce coagulation and anticoagulation fibrinolytic abnormalities. Anticoagulans activin C, antithrombin III and tissue factor pathway inhibitors have been found to play an important regulatory role in the inflammatory response. The use of exogenous anticoagulant replacement therapy can improve the prognosis of disease (activated protein C) or clinical manifestations (antithrombin III and tissue factor pathway inhibitors), for the treatment of infectious toxins and related diseases put forward a new direction