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在许多遗传性血红蛋白病中,只有镰状细胞病和地中海贫血(地贫)是卫生经费的主要消耗者。在许多发展中国家,血红蛋白病已成为一个严重的问题。婴儿死亡率随着对营养不良和传染病控制的进展而降低,这些遗传性疾病便成为一个日益严重的问题。这种情况已在地贫流行的地中海地区出现,现在,又在东南亚一些地区开始。由于下述原因,现在可以讨论预防常见血红蛋白病的可能途径。首先,日益认识到本病在欧洲以外地区的存在,收集了有关本病高发生率和临床严重性的引人注目的新资料,特别是东南亚。其次,分子生物学的飞跃发展及其
Of the many hereditary hemoglobinopathies, only sickle cell disease and thalassemia (thalassemia) are the major consumers of health funds. Hemoglobinopathy has become a serious problem in many developing countries. Infant mortality rates have diminished as malnutrition and control of infectious diseases have progressed, and these hereditary diseases have become a growing problem. This has occurred in the Mediterranean area where the poverty of thalastes prevails, and now it begins in some parts of South-East Asia. For the following reasons, now we can discuss the possible ways to prevent common hemoglobinopathies. First, the growing recognition of the presence of this disease outside Europe has gathered compelling new information on the high incidence and clinical severity of this disease, especially in South-East Asia. Second, the rapid development of molecular biology and its