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目的:研究胆管癌和正常胆管组织中TrkB蛋白的表达及其与临床病理特征的关系。方法:免疫组化检测42例胆管癌和10例正常胆管石蜡切片标本中TrkB蛋白的表达并分析其与临床病理因素的关系。结果:正常胆管组织中无TrkB蛋白的表达,胆管癌组织TrkB蛋白的表达率为69.0%(29/42)。TrkB表达与分化程度、有无淋巴结转移和远处转移有关,而与性别、年龄、肿瘤大小无关。TrkB蛋白在低分化组、有淋巴结转移组和有远处转移组中的表达率均高于高中分化组,无淋巴结转移组和无远处转移组(P<0.05)。结论:TrkB在胆管癌组织中的表达可作为预测胆管癌发生淋巴结转移和远处转移的指标。
Objective: To study the expression of TrkB protein in cholangiocarcinoma and normal bile duct and its relationship with clinicopathological features. Methods: TrkB protein was detected by immunohistochemistry in 42 cases of cholangiocarcinoma and 10 cases of normal bile duct paraffin sections and its relationship with clinicopathological parameters was analyzed. Results: The expression of TrkB protein in normal cholangiocarcinoma was 69.0% (29/42) without cholangiocarcinoma. TrkB expression and differentiation, with or without lymph node metastasis and distant metastasis, but not with gender, age, tumor size. The expression of TrkB protein in poorly differentiated group, lymph node metastasis group and distant metastasis group was higher than that in high differentiation group, no lymph node metastasis group and no distant metastasis group (P <0.05). Conclusion: The expression of TrkB in cholangiocarcinoma can be used as an index to predict the occurrence of lymph node metastasis and distant metastasis in cholangiocarcinoma.