近年来动脉粥样硬化在我国逐渐增多,该病是动脉硬化的血管病中最重要的一种,是心肌梗塞和脑梗塞的主要病因,也是中老年人死亡的主要原因之一。在我国已经证实,血小板源性的趋化因子——尤其是CXC-型趋化因子在动脉粥样硬化形成中发挥重要作用。因此,了解趋化因子的作用机制,可以为临床治疗动脉粥样硬化提供新的思路以及治疗靶点。 In recent years, atherosclerosis gradually increased in our country, the disease is the most important type of atherosclerotic vascular disease, is the main cause of myocardial infarction and cerebral infarction, but also one of the major causes of death in the elderly. It has been demonstrated in our country that platelet-derived chemokines, especially CXC-type chemokines, play an important role in the development of atherosclerosis. Therefore, to understand the mechanism of action of chemokines, can provide new ideas for clinical treatment of atherosclerosis and therapeutic targets.