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目的观察应用促红细胞生成素(EPO)治疗新生儿缺氧缺血性脑病(HIE)的临床效果。方法将126例HIE患儿随机分为治疗组和对照组,每组63例,患儿均采用常规治疗方法,治疗组在此基础上应用促红细胞生成素静脉注射,每周3次,疗程2周。记录两组患儿生后7、14、28 d新生儿行为神经测定(NBNA)评分,6月龄时进行智力发育指数(MDI)和心理运动发育指数(PDI)评分,生后30 d患儿头颅CT变化。结果两组患儿出生后7 d NBNA评分比较差异未见统计学意义(t=0.59,P>0.05),治疗组患儿生后14、28 d NBNA评分比较差异有统计学意义(t=4.79,P<0.05;t=7.59,P<0.05);生后30 d头颅CT结果显示,治疗组正常例数比较差异有统计学意义(χ2=7.01,P<0.01);两组患儿6月龄时MDI和PDI比较差异有统计学意义(t=11.67,P<0.05;t=10.06,P<0.05)。结论促红细胞生成素治疗HIE新生儿可以改善患儿神经系统症状,促进病情的恢复。
Objective To observe the clinical effect of erythropoietin (EPO) on neonatal hypoxic-ischemic encephalopathy (HIE). Methods 126 cases of children with HIE were randomly divided into treatment group and control group, each group of 63 cases, children were treated with conventional methods, the treatment group on this basis, the application of erythropoietin intravenously 3 times a week, treatment 2 week. The neonatal behavioral neurological assessment (NBNA) was recorded on the 7th, 14th, and 28th day after birth in children. The mental development index (MDI) and psychomotor developmental index (PDI) Head CT changes. Results There was no significant difference in NBNA score between the two groups at 7 days after birth (t = 0.59, P> 0.05). There was significant difference in NBNA score between the two groups at 14 and 28 days after birth (t = 4.79 , P <0.05; t = 7.59, P <0.05). The cranial CT findings at 30 days after birth showed that the number of normal cases in the treatment group was significantly different (χ2 = 7.01, P <0.01) The differences of MDI and PDI between the two groups were statistically significant (t = 11.67, P <0.05; t = 10.06, P <0.05). Conclusion Erythropoietin treatment of neonatal HIE can improve children with neurological symptoms and promote the recovery of the disease.