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对急、慢性精神分裂症病人99例和正常对照者51人的红细胞SOD、GPX及CAT活性进行了对比研究。结果发现,病人红细胞SOD活性与正常人比较具有非常显著意义的升高(t=3.9～7.46,P<0.001),急性组女性病人红细胞SOD活性显著高于男性病人(t=3.80,P<0.001)。各组间的GPX、CAT活性则无明显差异(P>0.05)。研究发现精神分裂症病人红细胞SOD活性改变与BPRS总分呈正相关(γ=0.588,P<0.05)。本研究结果表明,精神分裂症病人红细胞SOD活性明显增高,提示氧自由基在精神分裂症病因学或其精神病理过程中可能具有一定的作用。
99 cases of acute and chronic schizophrenia patients and 51 healthy controls were compared erythrocyte SOD, GPX and CAT activity were compared. The results showed that the erythrocyte superoxide dismutase (SOD) activity in patients with erythrocytes was significantly higher than that in healthy controls (t = 3.9-7.46, P <0.001) ). There was no significant difference in the activities of GPX and CAT between the two groups (P> 0.05). Study found that patients with schizophrenia erythrocyte SOD activity changes and the total score of BPRS was positively correlated (γ = 0.588, P <0.05). Our results show that patients with schizophrenia erythrocyte SOD activity was significantly increased, suggesting that oxygen free radicals in the etiology of schizophrenia or its psychopathological process may have a role.