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目的分析汇总深圳东部地区健康人群的胃蛋白酶原(PG)医学参考区间值范围,为进一步开展PG的普查提供理论支持,及临床上及时诊断萎缩性胃炎、早期胃癌等消化系统疾病提供依据。方法选择2014年7月—2015年12月在深圳市龙岗中心医院体检的健康人群400例,空腹采集肘静脉血,使用免疫比浊法检测血清中PGⅠ和PGⅡ的水平;采用百分位数法分析并确定血清PGⅠ和PGⅡ参考区间值范围。结果血清PGⅠ均值为(124.03±29.60)μg/L,血清PGⅡ均值为(7.57±5.23)μg/L,血清PGⅠ/PGⅡ均值为(27.07±24.44)。健康人群参考值范围为血清PGⅠ52.15~170.32μg/L,血清PGⅡ≤18.37μg/L,血清PGⅠ/PGⅡ≤6.59,该结果与国内常用参考标准之间差异显著。结论国内常用胃蛋白酶参考区间值范围可能不适用于深圳东部地区居民,应开展新型检测方案为本地区居民胃蛋白酶参考区间值范围提供制定依据。
Objective To analyze and summarize the value range of pepsinogen (PG) medical reference interval for healthy population in eastern Shenzhen, provide theoretical support for further screening of PG, and provide basis for clinical diagnosis of atrophic gastritis, early gastric cancer and other digestive diseases. Methods From July 2014 to December 2015, 400 healthy subjects were examined in Longgang Central Hospital of Shenzhen City. Elbow vein blood was collected on an empty stomach and serum PGⅠ and PGⅡ levels were measured by immunoturbidimetry. Analyze and determine the range of PGI and PGII reference interval values. Results The average serum PGI level was (124.03 ± 29.60) μg / L, serum PG Ⅱ level was (7.57 ± 5.23) μg / L, and serum PG Ⅰ / PG Ⅱ mean was (27.07 ± 24.44). The reference value of healthy people ranged from 152.15 to 170.32μg / L for PGⅠ, PGⅡ≤18.37μg / L for serum and PGⅠ / PGⅡ≤6.59 for serum. There was a significant difference between the results and other commonly used reference standards in China. CONCLUSIONS: The range of commonly used reference values of pepsin in China may not be suitable for residents in the eastern part of Shenzhen. A new detection scheme should be developed to provide reference for the pepsin reference interval value range of residents in this area.