论文部分内容阅读
前列腺分泌蛋白94( P S P94) 是前列腺腺泡分泌的一种蛋白质,目前已知它的基因结构和氨基酸顺序,并对 P S P94 的抗原决定簇,m R N A 不同剪接方式作了深入的探索。 P S P94 抑制前列腺组织的生长,诱导前列腺细胞凋亡,抑制体内外肿瘤细胞株的生长,抑制前列腺癌的生长,特别是激素非依赖性前列腺癌,其活性受类固醇激素的调节。 P S P94 可作为前列腺疾病诊断的潜在指标,并可能成为治疗前列腺癌的新的、无毒性的药物。
Prostate secretory protein 94 (P S P94) is a protein secreted by prostatic alveoli. Its gene structure and amino acid sequence are known at present, and the different splicing modes of m R N A, an antigenic determinant of P S P94, have been further studied Explore. P S P94 inhibits the growth of prostate tissue, induces apoptosis of prostate cells, inhibits the growth of tumor cell lines both in vitro and in vivo, and inhibits the growth of prostate cancer, especially hormone-independent prostate cancer, whose activity is regulated by steroid hormones. P S P94 can be a potential indicator of the diagnosis of prostate disease and may be a new, nontoxic drug for the treatment of prostate cancer.